Additional file 5: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Additional file 1: of Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

Vessela Vassileva (4056163)
Stephen Stribbling (6381179)
Chris Barnes (265806)
Laurence Carroll (3072045)
Marta Braga (6381182)
Joel Abrahams (6381185)
Kathrin Heinzmann (3762427)
Caroline Haegeman (6381191)
Marion MacFarlane (6381194)
Kathryn Simpson (2173090)
Caroline Dive (421487)
Jamie Honeychurch (6381200)
Timothy Illidge (6381206)
Eric Aboagye (3418220)

February 2019

Figure S1. PET imaging with apoptotic radiotracers. Representative PET images with (A) 18F-ICMT-11 a...

Additional file 2: of Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

Tyler Hulett (2317735)
Shawn Jensen (5060261)
Phillip Wilmarth (5060273)
Ashok Reddy (4399405)
Carmen Ballesteros-Merino (5060270)
Michael Afentoulis (5060267)
Christopher Dubay (5060264)
Larry David (826809)
Bernard Fox (2826419)

April 2018

Figure S1. Prophylactic autophagosome vaccination did not alter CD3 + CD4+ or CD3 + CD4 + FOXP3+ inf...

Additional file 4: of Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate

Christian Brand (1326921)
Ahmad Sadique (5696162)
Jacob Houghton (5696165)
Kishore Gangangari (5696168)
Jose Ponte (5696171)
Jason Lewis (4638244)
Naga Pillarsetty (5696174)
Jason Konner (5696177)
Thomas Reiner (848165)

August 2018

Figure S4. Serial PET imaging at 4 h, 24 h, 48 h, and 72 h post-administration of [89Zr]Zr-DFO-M9346...

Additional file 2: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S2. Initial response of splenic FDG uptake and T cells after a single vaccination (24Â h) dem...

Additional file 3: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S3. A: Comparison of in vivo FDG uptake in the spleen with and without partial volume correct...

Additional file 8: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S8. Balb/c mice were immunized two times (d0 and d7) with 20 μg gp70-LPX, liposomes alone, gp...

Additional file 7: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S7. Expression of activation marker CD6 on T cells after only one RNA-lipoplex vaccination cy...

Additional file 1: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S1. A: Liver as a reference organ showed no differences when compared to control. B: hybrid i...

Additional file 4: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S4. Non-antigen-specific cells (tetramer neg) did not upregulate CD25 expression. (JPG 129 kb

Additional file 2: Movie S2. of Modeling [18F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge

Svetlana Chefer (3765298)
David Thomasson (3765295)
Jurgen Seidel (2337409)
Richard Reba (3765304)
J. Bohannon (3765289)
Mathew Lackemeyer (3765301)
Chris Bartos (3765286)
Philip Sayre (3765292)
Laura Bollinger (473336)
Lisa Hensley (3459695)
Peter Jahrling (416495)
Reed Johnson (473335)

November 2015

Distribution and clearance of [18F]-FDG in the body measured via SUV. Dynamic images were taken over...

Additional file 1: Movie S1. of Modeling [18F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge

Svetlana Chefer (3765298)
David Thomasson (3765295)
Jurgen Seidel (2337409)
Richard Reba (3765304)
J. Bohannon (3765289)
Mathew Lackemeyer (3765301)
Chris Bartos (3765286)
Philip Sayre (3765292)
Laura Bollinger (473336)
Lisa Hensley (3459695)
Peter Jahrling (416495)
Reed Johnson (473335)

November 2015

Maximum intensity projection movie showing maximal [18F]-FDG uptake in mediastinal LNs in 3-D in one...

Additional file 7: of Leveraging PET to image folate receptor Îą therapy of an antibody-drug conjugate

Christian Brand (1326921)
Ahmad Sadique (5696162)
Jacob Houghton (5696165)
Kishore Gangangari (5696168)
Jose Ponte (5696171)
Jason Lewis (4638244)
Naga Pillarsetty (5696174)
Jason Konner (5696177)
Thomas Reiner (848165)

August 2018

Figure S7. Side-by-side comparison of the ex vivo biodistribution at 48Â h post-injection of [89Zr]Z...

Additional file 5: of Leveraging PET to image folate receptor Îą therapy of an antibody-drug conjugate

Christian Brand (1326921)
Ahmad Sadique (5696162)
Jacob Houghton (5696165)
Kishore Gangangari (5696168)
Jose Ponte (5696171)
Jason Lewis (4638244)
Naga Pillarsetty (5696174)
Jason Konner (5696177)
Thomas Reiner (848165)

August 2018

Figure S5. Ex vivo biodistribution study at 24Â h and 72Â h post-injection of [89Zr]Zr-DFO-M9346A in...

Additional file 5: Figure S3. of Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody

Yvonne Jauw (4787391)
Marc Huisman (180686)
Tapan Nayak (570788)
Danielle Vugts (4787403)
Randolph Christen (4787397)
Valerie Naegelen (4787385)
Dominik Ruettinger (4787394)
Florian Heil (4787400)
Adriaan Lammertsma (3763888)
Henk Verheul (4787388)
Otto Hoekstra (3552038)
Guus van Dongen (3552047)
C. Menke-van der Houven van Oordt (4787406)

January 2018

Additional examples of focal tumour uptake of 89Zr-RG7356 at 96Â h p.i.. From left to right: low dos...

Additional file 6: of Leveraging PET to image folate receptor Îą therapy of an antibody-drug conjugate

Christian Brand (1326921)
Ahmad Sadique (5696162)
Jacob Houghton (5696165)
Kishore Gangangari (5696168)
Jose Ponte (5696171)
Jason Lewis (4638244)
Naga Pillarsetty (5696174)
Jason Konner (5696177)
Thomas Reiner (848165)

August 2018

Figure S6. Ex vivo biodistribution study at 24Â h and 48Â h post-injection of [89Zr]Zr-DFO-M9346A in...

Additional file 1: of Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

Vessela Vassileva (4056163)
Stephen Stribbling (6381179)
Chris Barnes (265806)
Laurence Carroll (3072045)
Marta Braga (6381182)
Joel Abrahams (6381185)
Kathrin Heinzmann (3762427)
Caroline Haegeman (6381191)
Marion MacFarlane (6381194)
Kathryn Simpson (2173090)
Caroline Dive (421487)
Jamie Honeychurch (6381200)
Timothy Illidge (6381206)
Eric Aboagye (3418220)

February 2019

Figure S1. PET imaging with apoptotic radiotracers. Representative PET images with (A) 18F-ICMT-11 a...

Additional file 2: of Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

Tyler Hulett (2317735)
Shawn Jensen (5060261)
Phillip Wilmarth (5060273)
Ashok Reddy (4399405)
Carmen Ballesteros-Merino (5060270)
Michael Afentoulis (5060267)
Christopher Dubay (5060264)
Larry David (826809)
Bernard Fox (2826419)

April 2018

Figure S1. Prophylactic autophagosome vaccination did not alter CD3 + CD4+ or CD3 + CD4 + FOXP3+ inf...

Additional file 4: of Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate

Christian Brand (1326921)
Ahmad Sadique (5696162)
Jacob Houghton (5696165)
Kishore Gangangari (5696168)
Jose Ponte (5696171)
Jason Lewis (4638244)
Naga Pillarsetty (5696174)
Jason Konner (5696177)
Thomas Reiner (848165)

August 2018

Figure S4. Serial PET imaging at 4 h, 24 h, 48 h, and 72 h post-administration of [89Zr]Zr-DFO-M9346...

Additional file 2: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S2. Initial response of splenic FDG uptake and T cells after a single vaccination (24Â h) dem...

Additional file 3: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S3. A: Comparison of in vivo FDG uptake in the spleen with and without partial volume correct...

Additional file 8: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S8. Balb/c mice were immunized two times (d0 and d7) with 20 μg gp70-LPX, liposomes alone, gp...

Additional file 7: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S7. Expression of activation marker CD6 on T cells after only one RNA-lipoplex vaccination cy...

Additional file 1: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S1. A: Liver as a reference organ showed no differences when compared to control. B: hybrid i...

Additional file 4: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Stefanie Pektor (493377)
Lina Hilscher (5636087)
Kerstin Walzer (5636090)
Isabelle Miederer (5636093)
Nicole Bausbacher (1642201)
Carmen Loquai (103597)
Mathias Schreckenberger (582710)
Ugur Sahin (133198)
Mustafa Diken (133183)
Matthias Miederer (372618)

August 2018

Figure S4. Non-antigen-specific cells (tetramer neg) did not upregulate CD25 expression. (JPG 129 kb

Additional file 2: Movie S2. of Modeling [18F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge

Svetlana Chefer (3765298)
David Thomasson (3765295)
Jurgen Seidel (2337409)
Richard Reba (3765304)
J. Bohannon (3765289)
Mathew Lackemeyer (3765301)
Chris Bartos (3765286)
Philip Sayre (3765292)
Laura Bollinger (473336)
Lisa Hensley (3459695)
Peter Jahrling (416495)
Reed Johnson (473335)

November 2015

Distribution and clearance of [18F]-FDG in the body measured via SUV. Dynamic images were taken over...

Additional file 1: Movie S1. of Modeling [18F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge

Svetlana Chefer (3765298)
David Thomasson (3765295)
Jurgen Seidel (2337409)
Richard Reba (3765304)
J. Bohannon (3765289)
Mathew Lackemeyer (3765301)
Chris Bartos (3765286)
Philip Sayre (3765292)
Laura Bollinger (473336)
Lisa Hensley (3459695)
Peter Jahrling (416495)
Reed Johnson (473335)

November 2015

Maximum intensity projection movie showing maximal [18F]-FDG uptake in mediastinal LNs in 3-D in one...

Additional file 7: of Leveraging PET to image folate receptor Îą therapy of an antibody-drug conjugate

Christian Brand (1326921)
Ahmad Sadique (5696162)
Jacob Houghton (5696165)
Kishore Gangangari (5696168)
Jose Ponte (5696171)
Jason Lewis (4638244)
Naga Pillarsetty (5696174)
Jason Konner (5696177)
Thomas Reiner (848165)

August 2018

Figure S7. Side-by-side comparison of the ex vivo biodistribution at 48Â h post-injection of [89Zr]Z...

Additional file 5: of Leveraging PET to image folate receptor Îą therapy of an antibody-drug conjugate

Christian Brand (1326921)
Ahmad Sadique (5696162)
Jacob Houghton (5696165)
Kishore Gangangari (5696168)
Jose Ponte (5696171)
Jason Lewis (4638244)
Naga Pillarsetty (5696174)
Jason Konner (5696177)
Thomas Reiner (848165)

August 2018

Figure S5. Ex vivo biodistribution study at 24Â h and 72Â h post-injection of [89Zr]Zr-DFO-M9346A in...

Additional file 5: Figure S3. of Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody

Yvonne Jauw (4787391)
Marc Huisman (180686)
Tapan Nayak (570788)
Danielle Vugts (4787403)
Randolph Christen (4787397)
Valerie Naegelen (4787385)
Dominik Ruettinger (4787394)
Florian Heil (4787400)
Adriaan Lammertsma (3763888)
Henk Verheul (4787388)
Otto Hoekstra (3552038)
Guus van Dongen (3552047)
C. Menke-van der Houven van Oordt (4787406)

January 2018

Additional examples of focal tumour uptake of 89Zr-RG7356 at 96Â h p.i.. From left to right: low dos...

Additional file 6: of Leveraging PET to image folate receptor Îą therapy of an antibody-drug conjugate

Christian Brand (1326921)
Ahmad Sadique (5696162)
Jacob Houghton (5696165)
Kishore Gangangari (5696168)
Jose Ponte (5696171)
Jason Lewis (4638244)
Naga Pillarsetty (5696174)
Jason Konner (5696177)
Thomas Reiner (848165)

August 2018

Figure S6. Ex vivo biodistribution study at 24Â h and 48Â h post-injection of [89Zr]Zr-DFO-M9346A in...

Additional file 1: of Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

Vessela Vassileva (4056163)
Stephen Stribbling (6381179)
Chris Barnes (265806)
Laurence Carroll (3072045)
Marta Braga (6381182)
Joel Abrahams (6381185)
Kathrin Heinzmann (3762427)
Caroline Haegeman (6381191)
Marion MacFarlane (6381194)
Kathryn Simpson (2173090)
Caroline Dive (421487)
Jamie Honeychurch (6381200)
Timothy Illidge (6381206)
Eric Aboagye (3418220)

February 2019

Figure S1. PET imaging with apoptotic radiotracers. Representative PET images with (A) 18F-ICMT-11 a...

Additional file 2: of Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

Tyler Hulett (2317735)
Shawn Jensen (5060261)
Phillip Wilmarth (5060273)
Ashok Reddy (4399405)
Carmen Ballesteros-Merino (5060270)
Michael Afentoulis (5060267)
Christopher Dubay (5060264)
Larry David (826809)
Bernard Fox (2826419)

April 2018

Figure S1. Prophylactic autophagosome vaccination did not alter CD3 + CD4+ or CD3 + CD4 + FOXP3+ inf...

Additional file 4: of Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate

Christian Brand (1326921)
Ahmad Sadique (5696162)
Jacob Houghton (5696165)
Kishore Gangangari (5696168)
Jose Ponte (5696171)
Jason Lewis (4638244)
Naga Pillarsetty (5696174)
Jason Konner (5696177)
Thomas Reiner (848165)

August 2018

Figure S4. Serial PET imaging at 4 h, 24 h, 48 h, and 72 h post-administration of [89Zr]Zr-DFO-M9346...

Additional file 5: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Abstract

Extracted data

Additional file 5: of In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET

Abstract

Extracted data

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