A Genetic model. The K-RasG12V oncogene is activated after Cre-mediated excision of the STOP cassette. B In vivo approaches and imaging follow up. In the “pre-treatment” group, eight weeks old mice were transduced with AAV9 (Null, Tert or Tert-DN) vectors by tail vein injection and four weeks after they were infected with Adeno-CRE intratracheally. In the “simultaneous treatment” group, twelve weeks old mice were infected with AAV9 (Null, Tert or Tert-DN) by tail vein injection and with Adeno-CRE intratracheally at the same time. In both groups mice were analyzed every 8 weeks by computerized tomography (CT) until 32 weeks post-oncogene activation. Mice were sacrificed 40 weeks post-oncogene activation for further histological analysis. C-H...
<p>A Kaplan-Meier analysis of mortality due to tumor formation at the RCAS injection site of <i>p16/...
Transgenic mice carrying the activated rat c-neu oncogene under transcriptional control of the MMTV ...
<p>BOWES PCMV6 and CXCR3 cells were injected interdermally into NSG mice (5 x 10<sup>5</sup> cells p...
A-C Quantification of total number of hyperplasias (A), adenomas (B) and carcinomas (C) in pre-treat...
We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprote...
AbstractWe have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-RasV12 onc...
Adenocarcinoma of the lung is the most common form of lung cancer, but the cell of origin and the st...
The current model for cancer development envisions cells undergoing a series of genetic mutations an...
<p>Six to eight week old LSL-<i>Kras, Rb1</i><sup><i>+/+</i></sup> and LSL-<i>Kras, Rb1</i><sup>∆L/∆...
Two genetically engineered, conditional mouse models of lung tumor formation, K-rasLSL-G12D and K-ra...
<p>(A) For each xenograft model indicated, tumors were grown subcutaneously in female nude mice and ...
Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. Howe...
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Departamento de Biología Molecula...
Mutation of K-Ras is a frequent oncogenic event in human cancers, particularly cancers of lungs, pan...
<p>(a). Mice (3–4 months old) were subcutaneously injected with 0.25×10<sup>6</sup> B16 melanoma cel...
<p>A Kaplan-Meier analysis of mortality due to tumor formation at the RCAS injection site of <i>p16/...
Transgenic mice carrying the activated rat c-neu oncogene under transcriptional control of the MMTV ...
<p>BOWES PCMV6 and CXCR3 cells were injected interdermally into NSG mice (5 x 10<sup>5</sup> cells p...
A-C Quantification of total number of hyperplasias (A), adenomas (B) and carcinomas (C) in pre-treat...
We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprote...
AbstractWe have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-RasV12 onc...
Adenocarcinoma of the lung is the most common form of lung cancer, but the cell of origin and the st...
The current model for cancer development envisions cells undergoing a series of genetic mutations an...
<p>Six to eight week old LSL-<i>Kras, Rb1</i><sup><i>+/+</i></sup> and LSL-<i>Kras, Rb1</i><sup>∆L/∆...
Two genetically engineered, conditional mouse models of lung tumor formation, K-rasLSL-G12D and K-ra...
<p>(A) For each xenograft model indicated, tumors were grown subcutaneously in female nude mice and ...
Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. Howe...
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Departamento de Biología Molecula...
Mutation of K-Ras is a frequent oncogenic event in human cancers, particularly cancers of lungs, pan...
<p>(a). Mice (3–4 months old) were subcutaneously injected with 0.25×10<sup>6</sup> B16 melanoma cel...
<p>A Kaplan-Meier analysis of mortality due to tumor formation at the RCAS injection site of <i>p16/...
Transgenic mice carrying the activated rat c-neu oncogene under transcriptional control of the MMTV ...
<p>BOWES PCMV6 and CXCR3 cells were injected interdermally into NSG mice (5 x 10<sup>5</sup> cells p...