Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Previous studies suggest that the complement cascade plays a key role in IR injury in several systemic diseases. However, the role of the complement pathway in the ischemic retina has not been investigated. The aim of this study is to determine if the alternative complement cascade plays a role in retinal IR injury, and identify which components of the pathway mediate retinal degeneration in response to IR injury. To accomplish this, we utilized the mouse model of retinal IR injury, wherein the intraocular pressure (IOP) is elevated for 45 min, collapsing the retinal blood vessels and inducing retinal ischemia, followed by IOP normalization and...
Age-related macular degeneration (AMD) and Retinitis Pigmentosa (RP) are the most common cause of pr...
Background: The complement system (CS) plays a role in the pathogenesis of a number of ocular diseas...
Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. E...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Recent reports have indicated that components of the complement cascade are synthesized during the d...
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but...
Poorly controlled complement activation is now associated with many pathologies, and recent evidence...
The Author(s) 2015. This article is published with open access at Springerlink.com Abstract The loss...
Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss ...
Age-related macular degeneration (AMD) and Retinitis Pigmentosa (RP) are the most common cause of pr...
Background: The complement system (CS) plays a role in the pathogenesis of a number of ocular diseas...
Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. E...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Pr...
Recent reports have indicated that components of the complement cascade are synthesized during the d...
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but...
Poorly controlled complement activation is now associated with many pathologies, and recent evidence...
The Author(s) 2015. This article is published with open access at Springerlink.com Abstract The loss...
Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss ...
Age-related macular degeneration (AMD) and Retinitis Pigmentosa (RP) are the most common cause of pr...
Background: The complement system (CS) plays a role in the pathogenesis of a number of ocular diseas...
Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. E...