We report a new synthetic strategy that allows for the facile synthesis of acid-degradable poly(ethylene glycol) (PEG) with tunable acid sensitivity at physiologically relevant pH. This approach relies on the step-growth polymerization of telechelic OEG/PEG diamine and bis(maleic anhydride)s with the acid-cleavable maleamic acid derivatives formed in situ during the polymerization. These polymers are stable and negatively charged in neutral and basic aqueous solution, but in physiologically acidic media, they can be degraded selectively and completely into metabolizable bis(maleic acid)s and OEG/PEG diamines. The polymers derived from the short OEG diamine have been used as acid-responsive polyanions to coat the positively charged DNA/...
Smart biomaterials composed of pH responsive polymers, poly((meth)acrylic acid), were synthesized us...
Even after significant advances in polymerization and protein modification chemistries, the majority...
Stimuli-responsive degradation (SRD) undergoing chemical transition through the cleavage of labile l...
pH sensitive polymer systems can be utilized as smart nanocarriers to deliver hydrophobic drugs spec...
5The design and synthesis of a novel acid-degradable polyethylene glycol-based N-hydroxysuccinimide ...
Polyethylene glycol (PEG) has been used for decades to improve the pharmacokinetic properties of pro...
Poly(ethylene glycol) (PEG) with acid-sensitive moieties gained attention particularly for various ...
ABSTRACT: Poly(ethylene glycol) (PEG) represents the gold standard for stealth polymers in polymer-b...
Drawbacks of poly(ethylene glycol) (PEG), the most widely used water-soluble polymer in nanomedicin...
The synthetic polymers that are used to prepare polymer therapeutics reaching clinical use are predo...
International audienceThe design of smart nonviral vectors for gene delivery is of prime importance ...
Aromatic and aliphatic diacid chlorides were used to condense naturally occurring diamino acids and ...
PEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. De...
To enhance the limited degradability of poly(ethylene glycol) (PEG), a straightforward method of syn...
Poly(ethylene glycol) (PEG) is a biocompatible and water-soluble polymer that has a wide range of ap...
Smart biomaterials composed of pH responsive polymers, poly((meth)acrylic acid), were synthesized us...
Even after significant advances in polymerization and protein modification chemistries, the majority...
Stimuli-responsive degradation (SRD) undergoing chemical transition through the cleavage of labile l...
pH sensitive polymer systems can be utilized as smart nanocarriers to deliver hydrophobic drugs spec...
5The design and synthesis of a novel acid-degradable polyethylene glycol-based N-hydroxysuccinimide ...
Polyethylene glycol (PEG) has been used for decades to improve the pharmacokinetic properties of pro...
Poly(ethylene glycol) (PEG) with acid-sensitive moieties gained attention particularly for various ...
ABSTRACT: Poly(ethylene glycol) (PEG) represents the gold standard for stealth polymers in polymer-b...
Drawbacks of poly(ethylene glycol) (PEG), the most widely used water-soluble polymer in nanomedicin...
The synthetic polymers that are used to prepare polymer therapeutics reaching clinical use are predo...
International audienceThe design of smart nonviral vectors for gene delivery is of prime importance ...
Aromatic and aliphatic diacid chlorides were used to condense naturally occurring diamino acids and ...
PEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. De...
To enhance the limited degradability of poly(ethylene glycol) (PEG), a straightforward method of syn...
Poly(ethylene glycol) (PEG) is a biocompatible and water-soluble polymer that has a wide range of ap...
Smart biomaterials composed of pH responsive polymers, poly((meth)acrylic acid), were synthesized us...
Even after significant advances in polymerization and protein modification chemistries, the majority...
Stimuli-responsive degradation (SRD) undergoing chemical transition through the cleavage of labile l...