Using results from the simulations shown in Fig 9B(i-ii), we compared the densities of resistant parasites at the end of every 14-day treatment window to the densities that would be expected if the same infections had continued untreated for that 14-day period. For each treatment instance, the net gain is reported as the density of resistant parasites after 14 days of treatment minus the density expected after 14 days without treatment.</p
Slowing the evolution of antimicrobial resistance is essential if we are to continue to successfully...
Drug resistance is a serious problem in health care in general, and in malaria treatment in particul...
International audienceMalaria is one of the world׳s most widespread parasitic diseases. The parasiti...
The proportions of infections falling into each category (single and mixed) are shown above the box-...
Panels A–I vary in treatment rate (daily probability of infected host starting treatment) and fitnes...
Results are shown for low-transmission (b = 5) and high-transmission (b = 15) settings with high or ...
A major determinant of the rate at which drug-resistant malaria parasites spread through a populatio...
Abstract Background Malaria parasites that concurrently infect a host compete on the basis of their ...
Cumulative prevalence (total infection days) for resistant parasites in simulations with no antimala...
Drug resistance spreads through a population because (i) parasites can survive direct treatment and/...
Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial ...
A deterministic mathematical model which predicts the probability of developing a new drug-resistant...
<p>Two hypotheses on increased fitness in resistant parasites are compared in three panels A, B, C. ...
Emerging drug resistance and high-attrition rates in early and late stage drug development necessita...
Understanding the evolution of drug resistance in malaria is a central area of study at the intersec...
Slowing the evolution of antimicrobial resistance is essential if we are to continue to successfully...
Drug resistance is a serious problem in health care in general, and in malaria treatment in particul...
International audienceMalaria is one of the world׳s most widespread parasitic diseases. The parasiti...
The proportions of infections falling into each category (single and mixed) are shown above the box-...
Panels A–I vary in treatment rate (daily probability of infected host starting treatment) and fitnes...
Results are shown for low-transmission (b = 5) and high-transmission (b = 15) settings with high or ...
A major determinant of the rate at which drug-resistant malaria parasites spread through a populatio...
Abstract Background Malaria parasites that concurrently infect a host compete on the basis of their ...
Cumulative prevalence (total infection days) for resistant parasites in simulations with no antimala...
Drug resistance spreads through a population because (i) parasites can survive direct treatment and/...
Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial ...
A deterministic mathematical model which predicts the probability of developing a new drug-resistant...
<p>Two hypotheses on increased fitness in resistant parasites are compared in three panels A, B, C. ...
Emerging drug resistance and high-attrition rates in early and late stage drug development necessita...
Understanding the evolution of drug resistance in malaria is a central area of study at the intersec...
Slowing the evolution of antimicrobial resistance is essential if we are to continue to successfully...
Drug resistance is a serious problem in health care in general, and in malaria treatment in particul...
International audienceMalaria is one of the world׳s most widespread parasitic diseases. The parasiti...