a. Growing cell numbers over time in individual simulations (blue-green lines) and averaged between them (red line) reveals persistent dampening oscillations in the critical regime. b. Mean absolute autocorrelations near the critical regime. Δt, lag time after onset of toxin production. Toxin production rates with three zeroes indicate oscillatory solutions that converge slowly to the regimes of exponential growth or extinction. Vertical dashed line indicates peak lineage-growth rate mutual information; see Fig 4. N = 100 simulations for each toxin production rate.</p
Theory predicts that the approach of catastrophic thresholds in natural systems (e.g., ecosystems, t...
<p>(A) Correlation between reporter intensity and growth rate in response to stress. The growth rate...
During the endgame of elimination programs, parasite populations may exhibit dynamical phenomena not...
a. Average cellular growth rates (red) and toxin concentrations (blue) 150 minutes after onset of st...
Time proceeds downward in each lineage and begins at the onset of toxin production (t = 100 h). a. L...
<p>Panel A and B show the free toxin T (red) and free antitoxin A (green) level in the case of inter...
a. Simplified toxin-antitoxin module, depicting its interaction with cellular growth rate. b. Determ...
<p>The parameter scans for versus in the top panels show the percentage of cells (out of 200 simul...
A stochastic theory of cell kinetics has been developed based on a realistic model of cell prolifera...
<p>(A) Simulation output (time: 87 h) from a model as in <a href="http://www.ploscompbiol.org/articl...
<p>(<b>A</b>) Two representations of cells in the model during static equilibrium: (left) space-fill...
<p>The dashed line represents a culture growing in a rich medium, washed at time zero, and re-suspen...
<p>The black trace, representing the unsustainable simulation, grows quickly though never expands it...
AbstractA continuing goal in predictive microbiology is models directly based on physiological behav...
<p>Several groups have documented persistent MT growth (low catastrophe) in the cell interior. We si...
Theory predicts that the approach of catastrophic thresholds in natural systems (e.g., ecosystems, t...
<p>(A) Correlation between reporter intensity and growth rate in response to stress. The growth rate...
During the endgame of elimination programs, parasite populations may exhibit dynamical phenomena not...
a. Average cellular growth rates (red) and toxin concentrations (blue) 150 minutes after onset of st...
Time proceeds downward in each lineage and begins at the onset of toxin production (t = 100 h). a. L...
<p>Panel A and B show the free toxin T (red) and free antitoxin A (green) level in the case of inter...
a. Simplified toxin-antitoxin module, depicting its interaction with cellular growth rate. b. Determ...
<p>The parameter scans for versus in the top panels show the percentage of cells (out of 200 simul...
A stochastic theory of cell kinetics has been developed based on a realistic model of cell prolifera...
<p>(A) Simulation output (time: 87 h) from a model as in <a href="http://www.ploscompbiol.org/articl...
<p>(<b>A</b>) Two representations of cells in the model during static equilibrium: (left) space-fill...
<p>The dashed line represents a culture growing in a rich medium, washed at time zero, and re-suspen...
<p>The black trace, representing the unsustainable simulation, grows quickly though never expands it...
AbstractA continuing goal in predictive microbiology is models directly based on physiological behav...
<p>Several groups have documented persistent MT growth (low catastrophe) in the cell interior. We si...
Theory predicts that the approach of catastrophic thresholds in natural systems (e.g., ecosystems, t...
<p>(A) Correlation between reporter intensity and growth rate in response to stress. The growth rate...
During the endgame of elimination programs, parasite populations may exhibit dynamical phenomena not...