The problem of predicting small molecule-polymer compatibility is relevant to many areas of chemistry and pharmaceutical science but particularly drug delivery. Computational methods based on Hildebrand and Hansen solubility parameters, and the estimation of the Flory–Huggins parameter, χ, have proliferated across the literature. Focusing on the need to develop amorphous solid dispersions to improve the bioavailability of poorly soluble drug candidates, an innovative, high-throughput 2D printing method has been employed to rapidly assess the compatibility of 54 drug-polymer pairings (nine drug compounds in six polymers). In this study, the first systematic assessment of the in silico methods for this application, neither the solubility para...
For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polym...
In this study molecular modelling is introduced as a novel approach for the development of pharmaceu...
The solubility of drugs in polymer matrixes has been recognized as one of the key factors governing ...
© Copyright 2018 American Chemical Society. The problem of predicting small molecule-polymer compati...
In this study molecular modeling is introduced as a novel approach for the development of pharmaceut...
In this study molecular modeling is introduced as a novel approach for the development of pharmaceut...
Amorphous solid dispersions are known to enhance solubility of poorly aqueous-soluble drugs and subs...
Solubility of active pharmaceutical agents is a crucial process that determines drug absorption and ...
With the advent of combinatorial chemistry and high throughput screening of drug molecules, poorly w...
Amorphous solid dispersion (ASD) of a poorly soluble active pharmaceutical ingredient (API) in a pol...
Amorphous solid dispersions are considered a promising formulation strategy for the oral delivery of...
The evaluation of drug–polymer miscibility in the early phase of drug development is essential to en...
La dispersion moléculaire d’un principe actif (PA) dans un polymère est généralement utilisée pour a...
Amorphous drug–polymer systems or amorphous solid dispersions are commonly used in pharmaceutical in...
The poor aqueous solubility of hydrophobic drugs has always been a challenge for formulation scienti...
For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polym...
In this study molecular modelling is introduced as a novel approach for the development of pharmaceu...
The solubility of drugs in polymer matrixes has been recognized as one of the key factors governing ...
© Copyright 2018 American Chemical Society. The problem of predicting small molecule-polymer compati...
In this study molecular modeling is introduced as a novel approach for the development of pharmaceut...
In this study molecular modeling is introduced as a novel approach for the development of pharmaceut...
Amorphous solid dispersions are known to enhance solubility of poorly aqueous-soluble drugs and subs...
Solubility of active pharmaceutical agents is a crucial process that determines drug absorption and ...
With the advent of combinatorial chemistry and high throughput screening of drug molecules, poorly w...
Amorphous solid dispersion (ASD) of a poorly soluble active pharmaceutical ingredient (API) in a pol...
Amorphous solid dispersions are considered a promising formulation strategy for the oral delivery of...
The evaluation of drug–polymer miscibility in the early phase of drug development is essential to en...
La dispersion moléculaire d’un principe actif (PA) dans un polymère est généralement utilisée pour a...
Amorphous drug–polymer systems or amorphous solid dispersions are commonly used in pharmaceutical in...
The poor aqueous solubility of hydrophobic drugs has always been a challenge for formulation scienti...
For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polym...
In this study molecular modelling is introduced as a novel approach for the development of pharmaceu...
The solubility of drugs in polymer matrixes has been recognized as one of the key factors governing ...