Gene expression data analysed using gene set enrichment analysis (GSEA) to extract biological information.
- Jungho Yang (5683643)
- Kyueng-Whan Min (5683646)
- Dong-Hoon Kim (5683649)
- Byoung Kwan Son (5683652)
- Kyoung Min Moon (5683655)
- Young Chan Wi (5683658)
- Seong Sik Bang (5683661)
- Young Ha Oh (5683664)
- Sung-Im Do (5683667)
- Seoung Wan Chae (229254)
- Sukjoong Oh (5683670)
- Young Hwan Kim (132717)
- Mi Jung Kwon (5683673)
Publication date
August 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
In each thumbnail, the green curve represents the evolution of the density of the genes identified in the RNA-seq. GSEA calculates these by walking down the ranked-ordered list of genes, increasing a running-sum statistic when a gene is in the gene set and decreasing it when it is not. (A) TNFRSF12A was found commonly in four gene sets (IL15_UP.V1_UP, MTOR_UP.V1_UP, IL2_UP.V1_UP and PKCA_DN.V1_DN) with high MMP-9 expression. (B) High TNFRSF12A was associated with poor prognosis in three independent cohorts (METABRIC, GSE1456, and GSE20685).</p
Add to ORKG