Multimodal imaging of the left eye of a 49-year-old male patient with non-resolving central serous chorioretinopathy.

Fundus autofluorescence (FAF; A), fluorescein angiography (FA; B), indocyanine green angiography (ICGA; C), and optical coherence tomography (OCT; D) at last visit before half-dose photodynamic therapy (PDT). FAF (E), FA (F), ICGA (G), and OCT (H) at first visit at 10 weeks after PDT. Both hyperautofluorescent and hypoautofluorescent abnormalities are visible mainly in the fovea and nasal to the fovea on FAF (within the dashed borders; A). Two ‘hot spots’ of leakage on FA, nasal to the fovea (white arrows) and hyperfluorescent changes in the area below the fovea (B). Hyper- and hyporeflective abnormalities on ICGA (within the dashed borders), foveal and mainly in the area nasal to the fovea (C). Presence of foveal subretinal fluid (SRF) on OCT, with the presence of debris within the SRF accumulation (D). Abnormalities on FAF (within the dashed borders) did not change at the visit 10 weeks after PDT, compared to before PDT (E). One ‘hot spot’ of leakage is still present after PDT (arrow), with no obvious change in the hyperfluorescent areas that were already present (F). Hyper- and hyporeflective abnormalities showed subtle changes compared to before PDT (within the dashed borders) (G). A complete resolution of both SRF and hyperreflective subretinal debris was seen, with an improved integrity of the several neuroretinal layers (H).