Effect of danofloxacin concentration on loss of susceptibility and mutant enrichment.
- Nan Zhang (46264)
- Yuzhi Wu (2708437)
- Zilong Huang (3615194)
- Chuanzhen Zhang (5698283)
- Longfei Zhang (1918729)
- Qinren Cai (168153)
- Xiangguang Shen (3615185)
- Hongxia Jiang (2826611)
- Huanzhong Ding (3615188)
Publication date
August 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
M. gallisepticum strain S6 was inoculated into the IC and exposed for five consecutive days to once-daily danofloxacin replenishments in the in vitro dynamic model. Panels A1 to A7: Danofloxacin concentrations at the indicated times after the administration of each dose. Panels B1 to B7: Loss of susceptibility shown as an increase in average MIC for each group. Panels C1 to C7: The fraction of resistant mutants in each group was determined daily as the number of colonies grown on danofloxacin-containing agar (1 × MIC) relative to the number that grew on drug-free agar.</p
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