Parasite proliferation inhibition (PPI). The rows shaded in grey highlight the hit molecules.</p
<p>Mouse peritoneal macrophages were infected with <i>T</i>. <i>gondii</i> tachyzoites for 2h and th...
<p>(<b>A</b>) Axenic promastigotes were exposed to several concentrations of 17-AAG (25, 125, 500 nM...
<p>Eight chemical inhibitors were employed in this study. Depicted above are their chemical structur...
T. gondii proliferation inhibition activity and cytotoxicity of the six identified hits.</p
<p>GI<sub>50</sub> (µM) data for selected library members against cultured <i>P. falciparum</i> (W2 ...
<p>Growth inhibition curves of significant compounds are presented. Parasite cultures were exposed t...
<p><b>(A)</b> Parasite loads in spleen, blood and peritoneum, as indicated, 24 h post-inoculation of...
<p>(A, B) Dose responses for growth inhibition by ISG-21 and PRT-1 in standard medium and PGIM (blac...
Awareness is growing that drug target validation should involve systems analysis of cellular network...
Awareness is growing that drug target validation should involve systems analysis of cellular network...
(a-b) Preliminary screen outcome of 400 drug-like molecules in Pathogen Box as a measure of percenta...
<p>(A, B) Stacked graphs showing the number of invasions per rupture on top and matching deformation...
The protozoan parasite <i>Toxoplasma gondii</i> secretes a family of serine-threonine protein kinase...
<p>The TCAMS library of 13,533 compounds with demonstrated growth inhibitory activity against intrae...
<p>IC<sub>50</sub>, (µM) against five parasite cysteine proteases as determined for library compound...
<p>Mouse peritoneal macrophages were infected with <i>T</i>. <i>gondii</i> tachyzoites for 2h and th...
<p>(<b>A</b>) Axenic promastigotes were exposed to several concentrations of 17-AAG (25, 125, 500 nM...
<p>Eight chemical inhibitors were employed in this study. Depicted above are their chemical structur...
T. gondii proliferation inhibition activity and cytotoxicity of the six identified hits.</p
<p>GI<sub>50</sub> (µM) data for selected library members against cultured <i>P. falciparum</i> (W2 ...
<p>Growth inhibition curves of significant compounds are presented. Parasite cultures were exposed t...
<p><b>(A)</b> Parasite loads in spleen, blood and peritoneum, as indicated, 24 h post-inoculation of...
<p>(A, B) Dose responses for growth inhibition by ISG-21 and PRT-1 in standard medium and PGIM (blac...
Awareness is growing that drug target validation should involve systems analysis of cellular network...
Awareness is growing that drug target validation should involve systems analysis of cellular network...
(a-b) Preliminary screen outcome of 400 drug-like molecules in Pathogen Box as a measure of percenta...
<p>(A, B) Stacked graphs showing the number of invasions per rupture on top and matching deformation...
The protozoan parasite <i>Toxoplasma gondii</i> secretes a family of serine-threonine protein kinase...
<p>The TCAMS library of 13,533 compounds with demonstrated growth inhibitory activity against intrae...
<p>IC<sub>50</sub>, (µM) against five parasite cysteine proteases as determined for library compound...
<p>Mouse peritoneal macrophages were infected with <i>T</i>. <i>gondii</i> tachyzoites for 2h and th...
<p>(<b>A</b>) Axenic promastigotes were exposed to several concentrations of 17-AAG (25, 125, 500 nM...
<p>Eight chemical inhibitors were employed in this study. Depicted above are their chemical structur...
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