Agonist potencies (pEC50) and intrinsic activity (α), and antagonist potencies (pKB) of the compounds tested in the CHONOP cell DMR assay.</p
<p>(a) The dose-dependent kinetic DMR signals induced by D-luciferin; (b) the dose-dependent kinetic...
ABSTRACT. Many receptors mediating the effects of transmitter substances act by coupling to G-protei...
<p>Functional parameters were measured on CHO-K1 cells expressing ChemR23, CXCR4, CCR7 or combinatio...
Comparison of potencies (pEC50 + CL95%, panel A) and maximal effects (α+ SD, panel B) of NOP recepto...
<p>EC<sub>50</sub> values of agonists for Trica5-HT<sub>1</sub> receptor activation in CHO-WTA11 cel...
(A) CHO-K1 cells were transiently transfected with human HCA1, HCA2, HCA3, and empty vector (control...
<p>(A) Chemical structures of partial agonists MK-8666, MK-2305, TAK-875, AMG-837; and AgoPAMs AM-16...
a<p>Membranes from CHO cells stably transfected with human MOP, DOP or KOP receptors were used.</p>b...
<p>Representative traces of changes in fluorescence intensity over time after addition of pharmacolo...
<p>The traces in (A) are examples of inward currents elicited by low agonist concentrations (in µM) ...
Agonist efficacy is a measure of how well an agonist can stimulate a response system linked to a rec...
A protocol for predicting full agonist, partial agonist, and antagonist profiles of compounds with M...
(A) NPR-B agonist activity of CNP(1–22), CNP(1–22)/ghrelin(12–28), and ASB20123 was evaluated based ...
<p>Binding data from competition experiments were fitted assuming that receptors form homodimers, an...
A lack of selectivity of classical agonists for the nicotinic acetylcholine receptors (nAChR) has pr...
<p>(a) The dose-dependent kinetic DMR signals induced by D-luciferin; (b) the dose-dependent kinetic...
ABSTRACT. Many receptors mediating the effects of transmitter substances act by coupling to G-protei...
<p>Functional parameters were measured on CHO-K1 cells expressing ChemR23, CXCR4, CCR7 or combinatio...
Comparison of potencies (pEC50 + CL95%, panel A) and maximal effects (α+ SD, panel B) of NOP recepto...
<p>EC<sub>50</sub> values of agonists for Trica5-HT<sub>1</sub> receptor activation in CHO-WTA11 cel...
(A) CHO-K1 cells were transiently transfected with human HCA1, HCA2, HCA3, and empty vector (control...
<p>(A) Chemical structures of partial agonists MK-8666, MK-2305, TAK-875, AMG-837; and AgoPAMs AM-16...
a<p>Membranes from CHO cells stably transfected with human MOP, DOP or KOP receptors were used.</p>b...
<p>Representative traces of changes in fluorescence intensity over time after addition of pharmacolo...
<p>The traces in (A) are examples of inward currents elicited by low agonist concentrations (in µM) ...
Agonist efficacy is a measure of how well an agonist can stimulate a response system linked to a rec...
A protocol for predicting full agonist, partial agonist, and antagonist profiles of compounds with M...
(A) NPR-B agonist activity of CNP(1–22), CNP(1–22)/ghrelin(12–28), and ASB20123 was evaluated based ...
<p>Binding data from competition experiments were fitted assuming that receptors form homodimers, an...
A lack of selectivity of classical agonists for the nicotinic acetylcholine receptors (nAChR) has pr...
<p>(a) The dose-dependent kinetic DMR signals induced by D-luciferin; (b) the dose-dependent kinetic...
ABSTRACT. Many receptors mediating the effects of transmitter substances act by coupling to G-protei...
<p>Functional parameters were measured on CHO-K1 cells expressing ChemR23, CXCR4, CCR7 or combinatio...