Shigella flexneri is an important foodborne bacterial pathogen with infectious dose as low as 10–100 cells. SlyA, a transcriptional regulator of the MarR family, has been shown to regulate virulence in a closely related bacterial pathogen, Salmonella Typhimurium. However, the regulatory role of SlyA in S. flexneri is less understood. Here we applied unbiased proteomic profiling to define the SlyA regulon in S. flexneri. We found that the genetic ablation of slyA led to the alteration of 18 bacterial proteins among over 1400 identifications. Intriguingly, most down-regulated proteins (whose expression is SlyA-dependent) were associated with bacterial acid resistance such as the glutamate decarboxylation system. We further demonstrated that S...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
Quorum sensing (QS) coordinates population wide gene expression of bacterial species. Highly adaptiv...
Shigella flexneri is an important foodborne bacterial pathogen with infectious dose as low as 10–100...
Shigella flexneri is an important foodborne bacterial pathogen with infectious dose as low as 10–100...
Shigella flexneri is an important foodborne bacterial pathogen with infectious dose as low as 10–100...
Summary. The Salmonella regulatory protein SlyA is implicated in virulence, survival in macrophages ...
It is the enormous adaptive capacity of microorganisms, which is key to their competitive success in...
The Salmonella regulatory protein, SlyA is implicated in virulence, survival in macrophages and resi...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
It is the enormous adaptive capacity of microorganisms, which is key to their competitive success in...
Quorum sensing (QS) coordinates population wide gene expression of bacterial species. Highly adaptiv...
Enteric pathogens sense numerous signals specific to the anatomical location in the intestine and in...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
Quorum sensing (QS) coordinates population wide gene expression of bacterial species. Highly adaptiv...
Shigella flexneri is an important foodborne bacterial pathogen with infectious dose as low as 10–100...
Shigella flexneri is an important foodborne bacterial pathogen with infectious dose as low as 10–100...
Shigella flexneri is an important foodborne bacterial pathogen with infectious dose as low as 10–100...
Summary. The Salmonella regulatory protein SlyA is implicated in virulence, survival in macrophages ...
It is the enormous adaptive capacity of microorganisms, which is key to their competitive success in...
The Salmonella regulatory protein, SlyA is implicated in virulence, survival in macrophages and resi...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
It is the enormous adaptive capacity of microorganisms, which is key to their competitive success in...
Quorum sensing (QS) coordinates population wide gene expression of bacterial species. Highly adaptiv...
Enteric pathogens sense numerous signals specific to the anatomical location in the intestine and in...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
GntR family transcription factors have been implicated in the regulation of carbohydrate transport a...
Quorum sensing (QS) coordinates population wide gene expression of bacterial species. Highly adaptiv...