The immunologic events of <i>HLA-DRB3</i>*01, *02, *03 and the allele frequencies of <i>HLA-DRB1</i> in the donors.

a, b. The immunologic events defined as the HLA-DRB3 (*01, *02, *03) typing of the graft donors or children (pregnancies) and the reactivity patterns of HLA-DRB3 antibodies against LSA microbeads HLA-DRB3*01:01, *02:02, and *03:01 that were detected in HLA-DRB3 negative and positive kidney patients (n = 52). The percentages of the patients’ LSA reactivity pattern that correspond with the HLA-DRB3 donor typing are shown in the pie chart. The distribution of the HLA-DRB3 alleles of the graft donors or children are compared with a control group (HLA-DRB3 positive individuals without HLA-DRB3 antibodies). c. In 85 kidney patients HLA-DRB3 antibodies were detected. With respect to the donor group, 59 graft donors or children were typed for HLA-DRB1. These HLA-DRB1 alleles (linked to HLA-DRB3) were compared with a control group in a case-control setting. d. The allele frequencies of HLA-DRB1*03, *11, *12, *13, and *14 are displayed as percentage. The difference between donor and control groups was calculated using the Chi-squared test. The P values of <0.05 (*) and <0.01 (**) were statistically significant.