A) Mutant counts per wild-type (wt) -> mutant (mut) amino acid substitutions and B) Mutant type average dTm per wt -> mut substitutions, and C) Mutations per protein family.</p
Black dots: number of NS mutation per kb retrieved from each of the 32 variants sequenced. a, b and ...
<p>Genotype distribution of the PR mutations; (*1) wild type (G1031, G1978, and C2310) and (*2) muta...
Deep mutational scanning is a widely used method for multiplex measurement of functional consequence...
A) dTm density distribution and count of stabilizing (> 1°C), neutral ([–1,1]°C), and destabilizing ...
<p>Distribution of GFP-tagged wildtype and mutant stomatin between DRMs and non-DRMs.</p
Mutant (disorder-causing) allele frequency, f(m), for each disorder/breed per year of birth relative...
<p>Mutated amino acids are shown in rows; mutant amino acids are shown in columns associated with po...
a, the distribution of fitness for genotypes composed of combination of extant amino acid states (gr...
<p>Distribution of the growth phenotype of all 348,300 single gene knock-out mutants.</p
<p>Case 1 refers to the situation whereby all events, regardless of event lifetime, are analyzed. Th...
The distribution of fitness effects of new mutations is a fundamental parameter in genetics. Here we...
The amino acid distribution is plotted for the functionally neutral/beneficial mutations (left) and ...
Mutant (disorder-causing) allele frequency, f(m), for each disorder/breed per year of birth relative...
Distribution of mutations according to their functional category among the validation cohort.</p
<p>Estimated distribution of amino acid (AA) changes relative to the mutation rate (library size: 40...
Black dots: number of NS mutation per kb retrieved from each of the 32 variants sequenced. a, b and ...
<p>Genotype distribution of the PR mutations; (*1) wild type (G1031, G1978, and C2310) and (*2) muta...
Deep mutational scanning is a widely used method for multiplex measurement of functional consequence...
A) dTm density distribution and count of stabilizing (> 1°C), neutral ([–1,1]°C), and destabilizing ...
<p>Distribution of GFP-tagged wildtype and mutant stomatin between DRMs and non-DRMs.</p
Mutant (disorder-causing) allele frequency, f(m), for each disorder/breed per year of birth relative...
<p>Mutated amino acids are shown in rows; mutant amino acids are shown in columns associated with po...
a, the distribution of fitness for genotypes composed of combination of extant amino acid states (gr...
<p>Distribution of the growth phenotype of all 348,300 single gene knock-out mutants.</p
<p>Case 1 refers to the situation whereby all events, regardless of event lifetime, are analyzed. Th...
The distribution of fitness effects of new mutations is a fundamental parameter in genetics. Here we...
The amino acid distribution is plotted for the functionally neutral/beneficial mutations (left) and ...
Mutant (disorder-causing) allele frequency, f(m), for each disorder/breed per year of birth relative...
Distribution of mutations according to their functional category among the validation cohort.</p
<p>Estimated distribution of amino acid (AA) changes relative to the mutation rate (library size: 40...
Black dots: number of NS mutation per kb retrieved from each of the 32 variants sequenced. a, b and ...
<p>Genotype distribution of the PR mutations; (*1) wild type (G1031, G1978, and C2310) and (*2) muta...
Deep mutational scanning is a widely used method for multiplex measurement of functional consequence...
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