(A-F) The expression levels of IL-1β, TNF-α, IL-6, CCL2, IL-10 and PGE2 in the supernatants of lung homogenates of mice at therr days p.i., as determined by ELISA. Data are presented as means ± SEM from two or three independent experiments. * P P P P < 0.0001, n.s., not significant.</p
<p>We treated <i>Spred-2<sup>−/−</sup></i> mice intranasally with 20 µL of 5 mM U0126 (n = 6) or DMS...
<p>MIP-2 (A), IL-6 (B), TNF-α (C), and IFN-γ (D) were assayed by ELISA with undiluted lung lavage sa...
<p>B6 mice treated with isotype control (ISO) or anti-Gr-1 (α-Gr-1) antibody were infected with Δ<i>...
<p>Mice were injected intratracheally with LPS (50 µg in 50 µL) or vehicle (PBS). At 6 and 24 hours ...
<p>Cytokine contents in lung homogenates were assessed by ELISA for 4 mice in each group. The result...
<p>Protein concentrations for TNF-α (<b>A</b>) and IL-6R (<b>B</b>) were measured by ELISA on BAL fl...
(A) Number of CD4+ IFN-γ+ cells (left) and CD8+ IFN-γ+ cells (right) were determined by flow cytomet...
<p>(A) The lung tissues were isolated for Western blotting. Western blots showed that DJ-1 expressio...
<p>Lung slices from naïve mice were cultured in the absence or presence of LPS (10 μg/ml) for 2, 18 ...
<p>C57BL/6 (B6) or B6.C3H-<i>sst1</i> congenic mice were infected with <i>C. pneumoniae</i> (Cp) as ...
<p>Wild type (WT) and F508del CFTR mutation homozygote (d/d) mice (14-week-old females and males) we...
<p>(A) Alveolar macrophages were isolated from untreated WT and <i>Spred-2<sup>−/−</sup></i> mice (n...
<p>BALB/c mice were infected with 2.10<sup>7</sup> KR WT, 2.10<sup>7</sup> KR <i>cps</i><sup><i>-</i...
<p>The mice were treated as described in the legend to <a href="http://www.plosone.org/article/info:...
<p>The levels of cytokines in the lung tissue were assessed as described in the Methods. (open bar; ...
<p>We treated <i>Spred-2<sup>−/−</sup></i> mice intranasally with 20 µL of 5 mM U0126 (n = 6) or DMS...
<p>MIP-2 (A), IL-6 (B), TNF-α (C), and IFN-γ (D) were assayed by ELISA with undiluted lung lavage sa...
<p>B6 mice treated with isotype control (ISO) or anti-Gr-1 (α-Gr-1) antibody were infected with Δ<i>...
<p>Mice were injected intratracheally with LPS (50 µg in 50 µL) or vehicle (PBS). At 6 and 24 hours ...
<p>Cytokine contents in lung homogenates were assessed by ELISA for 4 mice in each group. The result...
<p>Protein concentrations for TNF-α (<b>A</b>) and IL-6R (<b>B</b>) were measured by ELISA on BAL fl...
(A) Number of CD4+ IFN-γ+ cells (left) and CD8+ IFN-γ+ cells (right) were determined by flow cytomet...
<p>(A) The lung tissues were isolated for Western blotting. Western blots showed that DJ-1 expressio...
<p>Lung slices from naïve mice were cultured in the absence or presence of LPS (10 μg/ml) for 2, 18 ...
<p>C57BL/6 (B6) or B6.C3H-<i>sst1</i> congenic mice were infected with <i>C. pneumoniae</i> (Cp) as ...
<p>Wild type (WT) and F508del CFTR mutation homozygote (d/d) mice (14-week-old females and males) we...
<p>(A) Alveolar macrophages were isolated from untreated WT and <i>Spred-2<sup>−/−</sup></i> mice (n...
<p>BALB/c mice were infected with 2.10<sup>7</sup> KR WT, 2.10<sup>7</sup> KR <i>cps</i><sup><i>-</i...
<p>The mice were treated as described in the legend to <a href="http://www.plosone.org/article/info:...
<p>The levels of cytokines in the lung tissue were assessed as described in the Methods. (open bar; ...
<p>We treated <i>Spred-2<sup>−/−</sup></i> mice intranasally with 20 µL of 5 mM U0126 (n = 6) or DMS...
<p>MIP-2 (A), IL-6 (B), TNF-α (C), and IFN-γ (D) were assayed by ELISA with undiluted lung lavage sa...
<p>B6 mice treated with isotype control (ISO) or anti-Gr-1 (α-Gr-1) antibody were infected with Δ<i>...