Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DNMs) will aid our understanding of the neurobiological and genetic basis of ID. In this study, we identify 63 high-confidence ID genes with q-values < 0.1 based on four background DNM rates and coding DNM data sets from multiple sequencing cohorts. Bioinformatic annotations revealed a higher burden of these 63 ID genes in FMRP targets and CHD8 targets, and these genes show evolutionary constraint against functional genetic variation. Moreover, these ID risk genes were preferentially expressed in the cortical regions from the early fetal to late mid-fetal stages. In particular, a genome-wide weighted co-expression network analysis suggested tha...
Genetic determinants of cognition are poorly characterized, and their relationship to genes that con...
Abstract Background Intellectual Disability (ID) is among the most common global disorders, yet etio...
Genetics is believed to have an important role in intellectual disability (ID). Recent studies have ...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Genetic determinants of cognition are poorly characterized, and their relationship to genes that con...
Genetic determinants of cognition are poorly characterized, and their relationship to genes that con...
Abstract Background Intellectual Disability (ID) is among the most common global disorders, yet etio...
Genetics is believed to have an important role in intellectual disability (ID). Recent studies have ...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DN...
Genetic determinants of cognition are poorly characterized, and their relationship to genes that con...
Genetic determinants of cognition are poorly characterized, and their relationship to genes that con...
Abstract Background Intellectual Disability (ID) is among the most common global disorders, yet etio...
Genetics is believed to have an important role in intellectual disability (ID). Recent studies have ...