Reduced fibrosis in tubule-specific <i>Jag1</i> knockout mice.

(A) Representative images of PAS-, Sirius Red-, and αSMA-stained kidney sections from CTL and Kspcre/Jag1flox/flox mice with or without FA injection. Scale bar: 20 μm. (B and C) Serum BUN and creatinine measurement of CTL and Kspcre Jag1flox/flox mice with or without FA injection. Data are represented as mean ± SD. * P P P n = 5, 3, 9, 10). (D and E) Relative mRNA amount of Notch signaling (D), fibrosis markers, dedifferentiation, and proliferation (E) in CTL and Kspcre Jag1flox/flox mice with or without FA injection. Data are represented as mean ± SD. * P P P P n = 5, 3, 9, 10). The underlying data of panels B–E can be found in S1 Data. αSMA, alpha smooth actin; BUN, blood urea nitrogen; CTL, control; FA, folic acid; PAS, Periodic acid–Schiff.