(A–C) Relative mRNA amount of Notch ligands and receptors in whole-kidney lysates of FA-induced nephropathy group (n = 7, 6) (A), sham and UUO group (n = 5, 5) (B), and APOL1-G1/G2 mice (n = 4, 7) as analyzed by qRT-PCR (C). Data are represented as the mean ± SD. *P P P P t test. The underlying data of panels A–C can be found in S1 Data. (D and E) Representative images of double staining of JAG1 (D) and NOTCH2 (E) with LTL, PNA, AQP2, or ATP6V1B1 on sham or FA-treated mouse kidneys. The arrow indicates an area of interest. Scale bar: 10 μm. APOL1-G1/G2, apolipoprotein L1-G1 and G2 risk alleles; AQP2, aquaporin 2; ATP6V1B1, ATPase H+ Transporting V1 Subunit B1; DAPI, diamidino-2-phenylindole; FA, folic acid; LTL, lotus lectin; PNA, peanut ag...
<div><p>Recent studies have described that the Notch signaling pathway is activated in a wide range ...
Kidney disease imparts a vast burden on affected individuals and the overall health care system. Pro...
The involvement of the Notch signaling pathway in the cellular differentiation of the mammalian kidn...
While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathway...
While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathway...
(A) Representative images of PAS-, Sirius Red-, and αSMA-stained kidney sections from CTL and Kspcre...
(A) Overlap of RBPJ ChIP-seq binding peaks with differentially expressed genes in kidneys of Pax8rtT...
(A) Representative images of PAS-, Sirius Red-, and αSMA-stained kidney sections from CTL and Kspcre...
(A and B) Correlation between interstitial fibrosis and JAG1 (A) or NOTCH2 (B) transcript level in 9...
AbstractWe previously determined that Notch2, and not Notch1, was required for forming proximal neph...
Recent studies indicate that the Notch signaling pathway plays an important role in the development ...
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily...
The role of Notch signaling in specification of podocyte and proximal tubules within the developing ...
<p>mRNA expression for (a) fibronectin, (b) PAI-1, (c) TIMP-1, (d) MMP-2 and (e) MMP-9 from kidneys....
International audienceKidney diseases impart a vast burden on affected individuals and the overall h...
<div><p>Recent studies have described that the Notch signaling pathway is activated in a wide range ...
Kidney disease imparts a vast burden on affected individuals and the overall health care system. Pro...
The involvement of the Notch signaling pathway in the cellular differentiation of the mammalian kidn...
While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathway...
While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathway...
(A) Representative images of PAS-, Sirius Red-, and αSMA-stained kidney sections from CTL and Kspcre...
(A) Overlap of RBPJ ChIP-seq binding peaks with differentially expressed genes in kidneys of Pax8rtT...
(A) Representative images of PAS-, Sirius Red-, and αSMA-stained kidney sections from CTL and Kspcre...
(A and B) Correlation between interstitial fibrosis and JAG1 (A) or NOTCH2 (B) transcript level in 9...
AbstractWe previously determined that Notch2, and not Notch1, was required for forming proximal neph...
Recent studies indicate that the Notch signaling pathway plays an important role in the development ...
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily...
The role of Notch signaling in specification of podocyte and proximal tubules within the developing ...
<p>mRNA expression for (a) fibronectin, (b) PAI-1, (c) TIMP-1, (d) MMP-2 and (e) MMP-9 from kidneys....
International audienceKidney diseases impart a vast burden on affected individuals and the overall h...
<div><p>Recent studies have described that the Notch signaling pathway is activated in a wide range ...
Kidney disease imparts a vast burden on affected individuals and the overall health care system. Pro...
The involvement of the Notch signaling pathway in the cellular differentiation of the mammalian kidn...