Figure S5. CDR-SB. Change from baseline (BL) of CDR-SB score in patients with mild-to-moderate AD (A and C) or mild AD (B and D) in the low-dose SC (A and B) and high-dose IV (C and D) cohorts. (PDF 112 kb
Effect of DcR3 on Aβ deposition in the hippocampus. (a) Immunostaining of total Aβ (6E10, Red) and n...
Inclusion and exclusion criteria. Inclusion and exclusion criteria, similar to those used in the 301...
Figure S5. Box plots for TP40 and TP42 by FBB-PET global SUVR status in SCD subjects. (JPEG 53 kb
Figure S4. CSF Aβ(1–42) crenezumab correlation analysis. Correlation analysis of change in CSF Aβ(1–...
Figure S3. FDG PET. FDG PET SUVR change from baseline in the low-dose SC (A) and high-dose IV (B) co...
Figure S1. SUVR longitudinal analysis. SUVR at week 69 compared to SUVR at baseline using different ...
Figure S2. vMRI. Analysis of vMRI change from baseline in the hippocampus (A and B), ventricular vol...
Supplementary methods and safety summary. PET imaging parameters and summary of safety findings. (PD...
Table S1. Summary of ARIA events. Summary of ARIA events in the low-dose SC cohort, high-dose IV coh...
Figure S1. Four-step screening process targeting biomarker-positive patients either as preclinical A...
Figure S2. Scatter plots for FBB-PET global SUVR and Aβ plasma ratios in SCD subjects. Correlations ...
Figure S1. Receiver operating characteristics (ROC) curves for (A) distinguishing between AD-dementi...
Results of multiple linear regression models without control for confounding variables. Values are β...
Figure S3. Linear regression between FBB-PET and Aβ TP42/40 plasma ratio in APOE ε4 stratification S...
Abstract Background We investigated the effect of crenezumab, a humanized anti-amyloid-beta (Aβ) imm...
Effect of DcR3 on Aβ deposition in the hippocampus. (a) Immunostaining of total Aβ (6E10, Red) and n...
Inclusion and exclusion criteria. Inclusion and exclusion criteria, similar to those used in the 301...
Figure S5. Box plots for TP40 and TP42 by FBB-PET global SUVR status in SCD subjects. (JPEG 53 kb
Figure S4. CSF Aβ(1–42) crenezumab correlation analysis. Correlation analysis of change in CSF Aβ(1–...
Figure S3. FDG PET. FDG PET SUVR change from baseline in the low-dose SC (A) and high-dose IV (B) co...
Figure S1. SUVR longitudinal analysis. SUVR at week 69 compared to SUVR at baseline using different ...
Figure S2. vMRI. Analysis of vMRI change from baseline in the hippocampus (A and B), ventricular vol...
Supplementary methods and safety summary. PET imaging parameters and summary of safety findings. (PD...
Table S1. Summary of ARIA events. Summary of ARIA events in the low-dose SC cohort, high-dose IV coh...
Figure S1. Four-step screening process targeting biomarker-positive patients either as preclinical A...
Figure S2. Scatter plots for FBB-PET global SUVR and Aβ plasma ratios in SCD subjects. Correlations ...
Figure S1. Receiver operating characteristics (ROC) curves for (A) distinguishing between AD-dementi...
Results of multiple linear regression models without control for confounding variables. Values are β...
Figure S3. Linear regression between FBB-PET and Aβ TP42/40 plasma ratio in APOE ε4 stratification S...
Abstract Background We investigated the effect of crenezumab, a humanized anti-amyloid-beta (Aβ) imm...
Effect of DcR3 on Aβ deposition in the hippocampus. (a) Immunostaining of total Aβ (6E10, Red) and n...
Inclusion and exclusion criteria. Inclusion and exclusion criteria, similar to those used in the 301...
Figure S5. Box plots for TP40 and TP42 by FBB-PET global SUVR status in SCD subjects. (JPEG 53 kb