Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis - Fig 4

Immunhistochemical detection of SP-A, -B, -C and -D in articular joint of STR/ort -mice. Red staining indicates positive antibody reactions. Overview and detail screen of mice at 4 months with stage of OA 0°; 9 months with stage of OA I°, 10 months with stage of OA II° and 12 months with stage of OA III°. All surfactant proteins detected at the femur (F) and tibia plateau (T) with layer of cartilage, the joint line (J) and the tidemark (arrow). For SP-B, SP-C and SP-D stage of OA III° no cartilage. Scale bars: 50 μm.