Vaccines may offer a new treatment strategy for opioid use disorders and opioid-related overdoses. To speed translation, this study evaluates opioid conjugate vaccines containing components suitable for pharmaceutical manufacturing and compares analytical assays for conjugate characterization. Three oxycodone-based haptens (OXY) containing either PEGylated or tetraglycine [(Gly)4] linkers were conjugated to a keyhole limpet hemocyanin (KLH) carrier protein via carbodiimide (EDAC) or maleimide chemistry. The EDAC-conjugated OXY(Gly)4-KLH was most effective in reducing oxycodone distribution to the brain in mice. Vaccine efficacy was T cell-dependent. The lead OXY hapten was conjugated to the KLH, tetanus toxoid, diphtheria cross-reactive ma...
In recent years, drug conjugate vaccines have shown promise as therapeutics for substance use disord...
Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a ...
The opioid epidemic is a global public health crisis that has failed to abate with current pharmaceu...
Opioid conjugate vaccines have shown promise in attenuating the behavioral effects of heroin or morp...
This study focused on formulating conjugate vaccines targeting oxycodone and heroin for technology t...
Vaccination against the highly abused prescription opioid oxycodone has shown pre-clinical efficacy ...
Vaccination against the highly abused prescription opioid oxycodone has shown pre-clinical efficacy ...
Among vaccines aimed at treating substance use disorders, those targeting opioids present several un...
Background: Increased death due to the opioid epidemic in the United States has necessitated the dev...
Among vaccines aimed at treating substance use disorders, those targeting opioids present several un...
Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effec...
Opioid use disorder (OUD) is a serious health problem that has dramatically increased over the last ...
Currently approved medications for opioid addiction have shown clinical efficacy, but undesired side...
The increase in heroin use is one factor contributing to the current opioid epidemic in the United S...
University of Minnesota Ph.D. dissertation. July 2013. Major: Pharmacology. Advisor: Paul Pentel. 1 ...
In recent years, drug conjugate vaccines have shown promise as therapeutics for substance use disord...
Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a ...
The opioid epidemic is a global public health crisis that has failed to abate with current pharmaceu...
Opioid conjugate vaccines have shown promise in attenuating the behavioral effects of heroin or morp...
This study focused on formulating conjugate vaccines targeting oxycodone and heroin for technology t...
Vaccination against the highly abused prescription opioid oxycodone has shown pre-clinical efficacy ...
Vaccination against the highly abused prescription opioid oxycodone has shown pre-clinical efficacy ...
Among vaccines aimed at treating substance use disorders, those targeting opioids present several un...
Background: Increased death due to the opioid epidemic in the United States has necessitated the dev...
Among vaccines aimed at treating substance use disorders, those targeting opioids present several un...
Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effec...
Opioid use disorder (OUD) is a serious health problem that has dramatically increased over the last ...
Currently approved medications for opioid addiction have shown clinical efficacy, but undesired side...
The increase in heroin use is one factor contributing to the current opioid epidemic in the United S...
University of Minnesota Ph.D. dissertation. July 2013. Major: Pharmacology. Advisor: Paul Pentel. 1 ...
In recent years, drug conjugate vaccines have shown promise as therapeutics for substance use disord...
Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a ...
The opioid epidemic is a global public health crisis that has failed to abate with current pharmaceu...