BackgroundType 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-causing pathways are incompletely understood and (2) subclassification may improve patient management. Unlike other biomarkers, germline genetic markers do not change with disease progression or treatment. In this paper, we test whether a germline genetic approach informed by physiology can be used to deconstruct T2D heterogeneity. First, we aimed to categorize genetic loci into groups representing likely disease mechanistic pathways. Second, we asked whether the novel clusters of genetic loci we identified have any broad clinical consequence, as assessed in four separate subsets of individuals with T2D.Methods and findingsIn an effort to identify mechanistic p...
SummaryType 2 diabetes is a genetically heterogeneous disease, with several relatively rare monogeni...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
Type 2 Diabetes (T2D) is an extremely heterogeneous disease, and the heritability of T2D is not full...
BackgroundType 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-causing pathways ar...
OBJECTIVEType 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In p...
Aims: Type 2 diabetes (T2D) is related to pathophysiological changes in metabolic and cardio-vascula...
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this he...
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this he...
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this he...
Genome-wide association studies have implicated around 250 genomic regions in predisposition to type...
Type 2 Diabetes (T2D) constitutes a global health burden. Efforts to uncover predisposing genetic va...
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between genetic, ep...
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this he...
Background and aims: Recent genome-wide association studies (GWAS) for human complex phenotypes have...
The genetic architecture of common traits, including the number, frequency, and effect sizes of inhe...
SummaryType 2 diabetes is a genetically heterogeneous disease, with several relatively rare monogeni...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
Type 2 Diabetes (T2D) is an extremely heterogeneous disease, and the heritability of T2D is not full...
BackgroundType 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-causing pathways ar...
OBJECTIVEType 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In p...
Aims: Type 2 diabetes (T2D) is related to pathophysiological changes in metabolic and cardio-vascula...
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this he...
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this he...
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this he...
Genome-wide association studies have implicated around 250 genomic regions in predisposition to type...
Type 2 Diabetes (T2D) constitutes a global health burden. Efforts to uncover predisposing genetic va...
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between genetic, ep...
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this he...
Background and aims: Recent genome-wide association studies (GWAS) for human complex phenotypes have...
The genetic architecture of common traits, including the number, frequency, and effect sizes of inhe...
SummaryType 2 diabetes is a genetically heterogeneous disease, with several relatively rare monogeni...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
Type 2 Diabetes (T2D) is an extremely heterogeneous disease, and the heritability of T2D is not full...