Upregulated NF-κB and E3 ligase mediated protein degradation in response to chronic hypoxia.

(A) Representative western blots for expression of NF-κB and Mafbx-1 in skeletal muscles and (B—D) Semiquantitative analysis of the expression of NF-κB, MAFbx-1and MuRF-1 is presented in the graph. The densitometric analysis is shown as mean ± SEM performed in n = 3 independent experiments. *p<0.05 Vs. Control; **p<0.01 Vs. Control; ***p<0.001 Vs. Control.