Mitochondrial function in the murine distal colon during <i>C</i>. <i>rodentium</i> infection with and without VIP administration.

Mice were harvested at day 10 and 14 post infection. VIP was administered daily in three treatment groups of mice: mice treated with VIP for day 5–10 were harvested both at day 10 and 14, and mice treated from day 5 to 14 and from day 10 to 14 post-infection were harvested on day 14. (A) complex I activity (B) complex II-III activity (C) complex IV activity (D) mitochondrial phosphorylation capacity (E) mitochondrial membrane potential (F) mitochondrial ATP generation. Statistics: data are presented as mean ± S.E.M. and analyzed by ANOVA with Student Newman-Keuls Multiple Comparison post hoc test: * P P P <0.001 vs. control. (n = 2–7 mice/group). Of the mice harvested day 14 post infection, one mouse died in the group that was administered VIP day 5–10 and two in the group that were administered VIP day 10–14. Data about dead animals is not included in the graphs, and the group with only two mice remaining (VIP day 10–14) was omitted from the statistical analysis.