Additional file 6: of Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease
- Michael Dumbacher (5795363)
- Tom Van Dooren (5795366)
- Katrien Princen (2304022)
- Koen De Witte (5795369)
- Mélissa Farinelli (174681)
- Sam Lievens (439826)
- Jan Tavernier (31436)
- Wim Dehaen (496141)
- Stefaan Wera (5795372)
- Joris Winderickx (23642)
- Sara Allasia (5795375)
- Amuri Kilonda (2688319)
- Stéphane Spieser (5795378)
- Arnaud Marchand (1656289)
- Patrick Chaltin (1656292)
- Casper Hoogenraad (3465326)
- Gerard Griffioen (5795381)
DOIAbstract
Figure S5. REM increases somatic and dendritic action potential AHP in hAPP brain slices. a K+ current analysis: left graph shows the total K+ current; right graph shows the 4-AP (IA channel blocker) insensitive current (n = 7 mice per condition; RM-two way ANOVA 4-AP insensitive current amplitude: Interaction: P = 0.0294; F(15,180) = 1.865; DF = 15; Sidak’s multiple comparison test: 60 mV: P = 0.0496; t = 2.988; DF = 192; 70 mV: P = 0.0088; t = 3.512; DF = 192). b Dendritic single AP parameters in hAPP brain slices after at least one hour vehicle or REM incubation; example traces are shown in the insets next to the graphs. (n = 8 mice per condition; AHP amplitude: P = 0.0003; t = 4.816; DF = 14; AP decay slope: P = 0.0317; t = 2.387; DF = ...
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