Additional file 2: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Additional file 2: Figure S2. of αVβ3 Integrin regulates astrocyte reactivity

Raúl Lagos-Cabré (669869)
Alvaro Alvarez (3538508)
Milene Kong (4480396)
Francesca Burgos-Bravo (4480393)
Areli Cárdenas (4480387)
Edgardo Rojas-Mancilla (4480384)
Ramón Pérez-Nuñez (4480390)
Rodrigo Herrera-Molina (174513)
Fabiola Rojas (4480399)
Pascal Schneider (46636)
Mario Herrera-Marschitz (19968)
Andrew Quest (4480402)
Brigitte van Zundert (547715)
Lisette Leyton (172553)

September 2017

Representative western blot of β3 Integrin from rat astrocytes treated with Il-6, IL+db cAMP, IL-1β,...

Additional file 2: of Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

Min Jian (394957)
Jason Kwan (164198)
Myriam Bunting (6739025)
Roy Ng (3539159)
Koon Chan (3539165)

May 2019

BV2 microglia in co-culture system exacerbated neuronal loss under AβO exposure. HT-22 cells were tr...

Additional file 3: of Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

Min Jian (394957)
Jason Kwan (164198)
Myriam Bunting (6739025)
Roy Ng (3539159)
Koon Chan (3539165)

May 2019

APN deficiency exacerbated astrogliosis in 5xFAD mice. (a) Representative images of GFAP immunoreact...

Additional file 1: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S2. Cell counting revealed 95.2% astrocytes and 4.5% microglia. Approximately 0.4% of the cel...

Additional file 5: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

November 2018

Figure S5. (A) Since there are no oligodendrocytes contaminating the cell culture, NLRP3-expression ...

Additional file 3: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S3. (A) Stimulation with Aβ1–42 led to a concentration-dependent LDH-release. For further exp...

Additional file 4: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

November 2018

Figure S4. No significant differences in cell metabolism were detected after increasing concentratio...

Additional file 2: of Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Ayaka Nakanishi (5952629)
Naoe Kaneko (5952632)
Hiroyuki Takeda (247055)
Tatsuya Sawasaki (29885)
Shinnosuke Morikawa (5952635)
Wei Zhou (24328)
Mie Kurata (551823)
Toshihiro Yamamoto (724226)
Sheikh Akbar (5952638)
Tamotsu Zako (195999)
Junya Masumoto (277060)

November 2018

Figure S2. MCC950 (A) and isoliquiritigenin (B), known NLRP3 inhibitors, did not affect the interact...

Additional file 6: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S6. (A) 10 μM Aβ1–42 significantly increased caspase 1 mRNA. Co-treatment with A1AT blocked t...

Additional file 1: of Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Ayaka Nakanishi (5952629)
Naoe Kaneko (5952632)
Hiroyuki Takeda (247055)
Tatsuya Sawasaki (29885)
Shinnosuke Morikawa (5952635)
Wei Zhou (24328)
Mie Kurata (551823)
Toshihiro Yamamoto (724226)
Sheikh Akbar (5952638)
Tamotsu Zako (195999)
Junya Masumoto (277060)

November 2018

Figure S1. Specificity of ALPHA-positive ratio for the interaction between Aβ and NLRP3 in compariso...

Additional file 1: of Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-ÎşB, Nrf2, and PPAR-Îł signaling pathways

Eun-Jung Lee (467478)
Jin-Sun Park (1623157)
Yu-Young Lee (6005909)
Do-Yeon Kim (161974)
Jihee Kang (5693258)
Hee-Sun Kim (199700)

November 2018

Figure S1. Quantitative real-time PCR (RT-qPCR) data showing the expressions of iNOS, COX-2, cytokin...

Additional file 1: of Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Li Zhong (51791)
Zongqi Wang (2840474)
Daxin Wang (707733)
Zhe Wang (41178)
Yuka Martens (5022662)
Linbei Wu (5022656)
Ying Xu (9172)
Kai Wang (21246)
Jianguo Li (174370)
Ruizhi Huang (429305)
Dan Can (5022659)
Huaxi Xu (302834)
Guojun Bu (77908)
Xiao-Fen Chen (262559)

March 2018

Figure S1. Oligomeric Aβ1–42 specifically binds to TREM2. Figure S2. Oligomeric Aβ1–42 specifically ...

Additional file 2: Figure S2. of Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models

Xiao-Long Sun (456137)
Bei-Yu Chen (456136)
Hai-Kang Zhao (3431324)
Ying-Ying Cheng (3431327)
Min-Hua Zheng (133095)
Li Duan (456135)
Wen Jiang (274586)
Liang-Wei Chen (294653)

July 2016

(A) Western blotting verification of Gas1 expression (H-300 antibody) and cleaved caspase-3 in SH-SY...

Additional file 2: of Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells

Soraya Saliba (3706465)
Hannah Jauch (5990432)
Brahim Gargouri (5279828)
Albrecht Keil (5990435)
Thomas Hurrle (5990438)
Nicole Volz (1947688)
Florian Mohr (5990441)
Mario van der Stelt (222751)
Stefan BrĂ¤se (4468327)
Bernd Fiebich (781952)

November 2018

First screening of chemical-related synthesized compounds (KIT 1 - KIT 21) on LPS-induced PGE2 synth...

Additional file 2: of Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Iliana Michailidou (3500087)
Aldo Jongejan (793996)
Jeroen Vreijling (5173688)
Theodosia Georgakopoulou (5173691)
Marit de Wissel (5173682)
Ruud Wolterman (5173694)
Patrick Ruizendaal (5173697)
Ngaisah Klar-Mohamad (4220899)
Anita Grootemaat (5173685)
Daisy Picavet (5173679)
Vinod Kumar (48743)
Cees van Kooten (795358)
Trent Woodruff (5173676)
B. Morgan (3500096)
Nicole van der Wel (252352)
Valeria Ramaglia (3466052)
Kees Fluiter (135713)
Frank Baas (23060)

May 2018

Figure S1. Systemic administration of C6 antisense knocks down C6 inÂ mice. Figure S2. QPCR determin...

Additional file 2: Figure S2. of αVβ3 Integrin regulates astrocyte reactivity

Raúl Lagos-Cabré (669869)
Alvaro Alvarez (3538508)
Milene Kong (4480396)
Francesca Burgos-Bravo (4480393)
Areli Cárdenas (4480387)
Edgardo Rojas-Mancilla (4480384)
Ramón Pérez-Nuñez (4480390)
Rodrigo Herrera-Molina (174513)
Fabiola Rojas (4480399)
Pascal Schneider (46636)
Mario Herrera-Marschitz (19968)
Andrew Quest (4480402)
Brigitte van Zundert (547715)
Lisette Leyton (172553)

September 2017

Representative western blot of β3 Integrin from rat astrocytes treated with Il-6, IL+db cAMP, IL-1β,...

Additional file 2: of Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

Min Jian (394957)
Jason Kwan (164198)
Myriam Bunting (6739025)
Roy Ng (3539159)
Koon Chan (3539165)

May 2019

BV2 microglia in co-culture system exacerbated neuronal loss under AβO exposure. HT-22 cells were tr...

Additional file 3: of Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

Min Jian (394957)
Jason Kwan (164198)
Myriam Bunting (6739025)
Roy Ng (3539159)
Koon Chan (3539165)

May 2019

APN deficiency exacerbated astrogliosis in 5xFAD mice. (a) Representative images of GFAP immunoreact...

Additional file 1: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S2. Cell counting revealed 95.2% astrocytes and 4.5% microglia. Approximately 0.4% of the cel...

Additional file 5: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

November 2018

Figure S5. (A) Since there are no oligodendrocytes contaminating the cell culture, NLRP3-expression ...

Additional file 3: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S3. (A) Stimulation with Aβ1–42 led to a concentration-dependent LDH-release. For further exp...

Additional file 4: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

November 2018

Figure S4. No significant differences in cell metabolism were detected after increasing concentratio...

Additional file 2: of Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Ayaka Nakanishi (5952629)
Naoe Kaneko (5952632)
Hiroyuki Takeda (247055)
Tatsuya Sawasaki (29885)
Shinnosuke Morikawa (5952635)
Wei Zhou (24328)
Mie Kurata (551823)
Toshihiro Yamamoto (724226)
Sheikh Akbar (5952638)
Tamotsu Zako (195999)
Junya Masumoto (277060)

November 2018

Figure S2. MCC950 (A) and isoliquiritigenin (B), known NLRP3 inhibitors, did not affect the interact...

Additional file 6: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S6. (A) 10 μM Aβ1–42 significantly increased caspase 1 mRNA. Co-treatment with A1AT blocked t...

Additional file 1: of Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Ayaka Nakanishi (5952629)
Naoe Kaneko (5952632)
Hiroyuki Takeda (247055)
Tatsuya Sawasaki (29885)
Shinnosuke Morikawa (5952635)
Wei Zhou (24328)
Mie Kurata (551823)
Toshihiro Yamamoto (724226)
Sheikh Akbar (5952638)
Tamotsu Zako (195999)
Junya Masumoto (277060)

November 2018

Figure S1. Specificity of ALPHA-positive ratio for the interaction between Aβ and NLRP3 in compariso...

Additional file 1: of Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-ÎşB, Nrf2, and PPAR-Îł signaling pathways

Eun-Jung Lee (467478)
Jin-Sun Park (1623157)
Yu-Young Lee (6005909)
Do-Yeon Kim (161974)
Jihee Kang (5693258)
Hee-Sun Kim (199700)

November 2018

Figure S1. Quantitative real-time PCR (RT-qPCR) data showing the expressions of iNOS, COX-2, cytokin...

Additional file 1: of Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Li Zhong (51791)
Zongqi Wang (2840474)
Daxin Wang (707733)
Zhe Wang (41178)
Yuka Martens (5022662)
Linbei Wu (5022656)
Ying Xu (9172)
Kai Wang (21246)
Jianguo Li (174370)
Ruizhi Huang (429305)
Dan Can (5022659)
Huaxi Xu (302834)
Guojun Bu (77908)
Xiao-Fen Chen (262559)

March 2018

Figure S1. Oligomeric Aβ1–42 specifically binds to TREM2. Figure S2. Oligomeric Aβ1–42 specifically ...

Additional file 2: Figure S2. of Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models

Xiao-Long Sun (456137)
Bei-Yu Chen (456136)
Hai-Kang Zhao (3431324)
Ying-Ying Cheng (3431327)
Min-Hua Zheng (133095)
Li Duan (456135)
Wen Jiang (274586)
Liang-Wei Chen (294653)

July 2016

(A) Western blotting verification of Gas1 expression (H-300 antibody) and cleaved caspase-3 in SH-SY...

Additional file 2: of Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells

Soraya Saliba (3706465)
Hannah Jauch (5990432)
Brahim Gargouri (5279828)
Albrecht Keil (5990435)
Thomas Hurrle (5990438)
Nicole Volz (1947688)
Florian Mohr (5990441)
Mario van der Stelt (222751)
Stefan BrĂ¤se (4468327)
Bernd Fiebich (781952)

November 2018

First screening of chemical-related synthesized compounds (KIT 1 - KIT 21) on LPS-induced PGE2 synth...

Additional file 2: of Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Iliana Michailidou (3500087)
Aldo Jongejan (793996)
Jeroen Vreijling (5173688)
Theodosia Georgakopoulou (5173691)
Marit de Wissel (5173682)
Ruud Wolterman (5173694)
Patrick Ruizendaal (5173697)
Ngaisah Klar-Mohamad (4220899)
Anita Grootemaat (5173685)
Daisy Picavet (5173679)
Vinod Kumar (48743)
Cees van Kooten (795358)
Trent Woodruff (5173676)
B. Morgan (3500096)
Nicole van der Wel (252352)
Valeria Ramaglia (3466052)
Kees Fluiter (135713)
Frank Baas (23060)

May 2018

Figure S1. Systemic administration of C6 antisense knocks down C6 inÂ mice. Figure S2. QPCR determin...

Additional file 2: Figure S2. of αVβ3 Integrin regulates astrocyte reactivity

Raúl Lagos-Cabré (669869)
Alvaro Alvarez (3538508)
Milene Kong (4480396)
Francesca Burgos-Bravo (4480393)
Areli Cárdenas (4480387)
Edgardo Rojas-Mancilla (4480384)
Ramón Pérez-Nuñez (4480390)
Rodrigo Herrera-Molina (174513)
Fabiola Rojas (4480399)
Pascal Schneider (46636)
Mario Herrera-Marschitz (19968)
Andrew Quest (4480402)
Brigitte van Zundert (547715)
Lisette Leyton (172553)

September 2017

Representative western blot of β3 Integrin from rat astrocytes treated with Il-6, IL+db cAMP, IL-1β,...

Additional file 2: of Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

Min Jian (394957)
Jason Kwan (164198)
Myriam Bunting (6739025)
Roy Ng (3539159)
Koon Chan (3539165)

May 2019

BV2 microglia in co-culture system exacerbated neuronal loss under AβO exposure. HT-22 cells were tr...

Additional file 3: of Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

Min Jian (394957)
Jason Kwan (164198)
Myriam Bunting (6739025)
Roy Ng (3539159)
Koon Chan (3539165)

May 2019

APN deficiency exacerbated astrogliosis in 5xFAD mice. (a) Representative images of GFAP immunoreact...

Additional file 2: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Abstract

Extracted data

Additional file 2: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Abstract

Extracted data

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