Functional classification of differentially expressed genes in the regenerating earthworm.
- Aksheev Bhambri (5797613)
- Neeraj Dhaunta (5797616)
- Surendra Singh Patel (5797619)
- Mitali Hardikar (5797622)
- Abhishek Bhatt (5797625)
- Nagesh Srikakulam (5797628)
- Shruti Shridhar (5797631)
- Shamsudheen Vellarikkal (4858948)
- Rajesh Pandey (4378585)
- Rijith Jayarajan (2183703)
- Ankit Verma (2183700)
- Vikram Kumar (2564392)
- Pradeep Gautam (5586800)
- Yukti Khanna (5797634)
- Jameel Ahmed Khan (5797637)
- Bastian Fromm (3453845)
- Kevin J. Peterson (276002)
- Vinod Scaria (19350)
- Sridhar Sivasubbu (67797)
- Beena Pillai (19351)
Publication date
September 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) Schematic representation of the experiment: Earthworms were cut (transverse) at 60 ± 6 segments from the anterior end and anterior portion was allowed to regenerate for 15, 20 or 30 days. At 15, 20 and 30 days post amputation (dpa), the regenerated tissue and the (old) adjacent control tissue was collected. Total RNA was used for RNA-Seq analysis. (B) A typical worm during various stages of regeneration showing the regenerating tissue (filled arrowhead) and the adjacent tissue (open arrowhead). Gene ontology classification by DAVID revealed GO terms over-represented in the (C-D) upregulated genes and (E-F) downregulated genes (Benjamini Hochberg adjusted pVal ≤ 10-4).</p
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