Twelve-Step Asymmetric Synthesis of (−)-Nodulisporic Acid C

A short, enantioselective synthesis of (−)-nodulisporic acid C is described. The route features two highly diastereoselective polycyclizations en route to the terpenoid core and the indenopyran fragment and a highly convergent assembly of a challenging indole moiety. Application of this chemistry allows for a 12-step synthesis of the target indoloterpenoid from commercially available material