Retinal degeneration of flies with altered RH1 phosphorylation was assessed by different readouts. A, Representative images of the deep pseudopupils (DPP) of flies with the indicated genotypes after 0 and 7 days in a 12 h light/12 h dark cycle. Scale bar, 100 μm. B, Percentage of flies exhibiting a DPP after 0 to 7 days in the light/dark cycle. For each time point, at least 12 flies were imaged. C, Cross sections through the eyes of rdgCΔS, rdgCΔSM, rdgCΔL, and control flies after 0 or 7 days in the light/dark cycle. AlexaFluor546-coupled phalloidin was used to label the rhabdomeres. Scale bar, 10 μm.</p
<p>(A) Quantification of relative ERG amplitudes from control, <i>kdn</i><sup><i>16A</i></sup>, and ...
<p>(A–C) Detection of ROS levels by DHE (red) staining in <i>ppr</i> mutant clones in eye imaginal d...
Dark-reared, one day old flies received two orange light pulses and 20 blue light pulses of 10 sec d...
A, Heads of flies lacking RDGC-S (rdgCΔS), RDGC-S and RDGC-M (rdgCΔSM), and RDGC-L (rdgCΔL) as well ...
<p>(A) Whole mount staining of photoreceptors of flies raised in the dark. Note that Rh1, InaD, and ...
<p>Representative images of the GFP fluorescence in intact eyes are shown. (A-E) The green fluoresci...
<p>(A) Western blots of proteins regulating phototransduction. Protein was extracted from heads of f...
<p>(A) In adult flies, blue light triggers the conformational change of Rh to metaRh, whereas orange...
<div><p>The <i>Drosophila</i> visual system has been proved to be a powerful genetic model to study ...
<p>(A) ERG traces from control (top) or <i>ppr</i><sup><i>A</i></sup> (bottom) eye clones. Flies wer...
<p><b>A.</b> A 30 d old control fly carrying only the GMR-GAL4 construct reveals an intact retina. <...
Drosophila retinal degeneration C (RDGC) is the founding member of the PPEF family of protein phosph...
Drosophila retinal degeneration C (RDGC) is the founding member of the PPEF family of protein phosph...
<p>(A) Decreasing endocytosis with a temperature-sensitive dynamin mutation (<i>shi<sup>ts</sup></i>...
<p>(A-E) Detection of fluorescence in the deep pseudopupil (left panels) and by cornea optical neutr...
<p>(A) Quantification of relative ERG amplitudes from control, <i>kdn</i><sup><i>16A</i></sup>, and ...
<p>(A–C) Detection of ROS levels by DHE (red) staining in <i>ppr</i> mutant clones in eye imaginal d...
Dark-reared, one day old flies received two orange light pulses and 20 blue light pulses of 10 sec d...
A, Heads of flies lacking RDGC-S (rdgCΔS), RDGC-S and RDGC-M (rdgCΔSM), and RDGC-L (rdgCΔL) as well ...
<p>(A) Whole mount staining of photoreceptors of flies raised in the dark. Note that Rh1, InaD, and ...
<p>Representative images of the GFP fluorescence in intact eyes are shown. (A-E) The green fluoresci...
<p>(A) Western blots of proteins regulating phototransduction. Protein was extracted from heads of f...
<p>(A) In adult flies, blue light triggers the conformational change of Rh to metaRh, whereas orange...
<div><p>The <i>Drosophila</i> visual system has been proved to be a powerful genetic model to study ...
<p>(A) ERG traces from control (top) or <i>ppr</i><sup><i>A</i></sup> (bottom) eye clones. Flies wer...
<p><b>A.</b> A 30 d old control fly carrying only the GMR-GAL4 construct reveals an intact retina. <...
Drosophila retinal degeneration C (RDGC) is the founding member of the PPEF family of protein phosph...
Drosophila retinal degeneration C (RDGC) is the founding member of the PPEF family of protein phosph...
<p>(A) Decreasing endocytosis with a temperature-sensitive dynamin mutation (<i>shi<sup>ts</sup></i>...
<p>(A-E) Detection of fluorescence in the deep pseudopupil (left panels) and by cornea optical neutr...
<p>(A) Quantification of relative ERG amplitudes from control, <i>kdn</i><sup><i>16A</i></sup>, and ...
<p>(A–C) Detection of ROS levels by DHE (red) staining in <i>ppr</i> mutant clones in eye imaginal d...
Dark-reared, one day old flies received two orange light pulses and 20 blue light pulses of 10 sec d...