Mechanosensitivity of wound closure.

A-B: Dependence of closure time (A) and mean strain energy (B) for different values of substrate stiffness (Es) and kp. Starred cells indicate the fastest wound closure for a given Es with varying kp (PS: kp = 1000 hr−1; C: kp = 0). Each data point corresponds to the average of 5 simulations. C: Pearson’s correlation coefficient, r, between closure time and substrate stiffness, for crawling (kp = 0), purse-string (kp = 1000 hr−1), and mixed (kp = 4 hr−1) modes of closure. The asterisk represents coefficients significantly different from zero (pkp = 0), purse-string (kp = 1000 hr−1), and mixed (kp = 4 hr−1) modes of migration. Error bars represent standard deviation (n = 5).