Surviving male mice born from DIO or lean dams do not display differences in feeding behavior.

Male offspring weaned from dams fed a standard chow diet (SD) or a Western diet (WD) were given ad libitum access to standard chow for 8 weeks. Body weights were monitored and feeding behavior was tested. WD offspring had higher body mass at time of wean but body weights were rapidly normalized over the monitoring period (a). There were no differences meal size, rate of intake, meal duration, meal frequency, total caloric intake, dark cycle intake, light cycle intake, or in post meal interval (b-i). The offspring also displayed no difference in preference when given the choice between consuming a standard chow and highly palatable western diet (j). Data analyzed using repeated measures two-way ANOVA, with Sidak's multiple comparison post hoc test, ** = p0.05 (a); unpaired Student's t-test (two-tailed), ns = p>0.05 between SD and WD (b-j). Results are expressed as means ± SEM; n = 8/9 (SD/WD).