Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction of α‑Diazoacetates and β‑Trifluoromethyl Enones: A Facile Access to Multisubstituted 4‑(Trifluoromethyl)pyrazolines
- Yongfeng Li (135567)
- Huamin Wang (143068)
- Yuwei Su (5810948)
- Runchen Li (5810951)
- Cao Li (740471)
- Lu Liu (171341)
- Junliang Zhang (1470220)
Publication date
October 2018
DOI Publisher
American Chemical Society (ACS)Abstract
A novel phosphine-catalyzed [3 + 2] cycloaddition of α-diazoacetates and β-trifluoromethyl enones has been developed that provides facile access to multisubstituted 4-(trifluoromethyl)pyrazolines in good to excellent yields at room temperature. In addition, a tandem [3 + 2] cycloaddition/Michael addition is also presented
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