Comparative sequencing performance between amplicon sequencing with high fidelity polymerase (top) and Pro-Seq (bottom).

A wild-type plasma sample was sequenced using a 19-amplicon panel with both methods, and the FPR plotted per base position. Amplicon sequencing (grey) has an average FPR of 1.2 x 10−4 errors per base, compared to Pro-Seq (green), which had an average FPR of 1.1 x 10−6 errors per base (a known SNP at panel position 237 is ignored for FPR calculations).