Effect of the inhibition strength <i>α</i> on the cell cycle regulation in response to glucose fluctuation.

(A-C) Time courses of variables in cell cycle (CycB, Cdh1, p55cdcT, p55cdcA, plk1, volume, and masss) and miR-451-AMPK-mTOR module in response to a periodically fluctuating glucose level (G(t) = 0.45*cos(π*t/20) + 0.5) when α = 1.0 (low), 1.6 (base), 2.5 (high). When α is decreased (α = α* → 1.0 in (A)) or increased (α = α* → 1.0 in (C)) from the base value (α* = 1.6), the system leads to quantitatively different durations of normal cell cycle and G0-phase. (D) Distribution of normal cell cycles and quiescent phase for various α’s (α = 1.0, 1.6, 2.0, 2.5). As α is increased, average duration of G0-phase (red bar) is increased and the total number of normal cell cycles (black circle) is decreased.