A: MFG-E8-/- mice were crossed with 56R anti-dsDNA BCR transgenic mice. The percentages of non-autoreactive 56R/Vκ21D and autoreactive 56R/Vκ38c B cells in the spleens of 3 month old female mice were determined by idiotype specific antibodies using flow cytometry (left) and Immunofluorescence staining (right). The images are representative of at least 5 mice in each strain. B: Mertk-/- mice were crossed with 56R mice. The percentages of non-autoreactive 56R/Vκ21D and autoreactive 56R/Vκ38c in the spleens were determined by flow cytometry. C: Bone marrow from CD45.1+ w.t. or MFG-E8-/- mice was mixed with genotype matched bone marrow from CD45.2+56R mice at a 1:1 ratio. The mixed bone marrow cells were used to reconstitute irradiated CD45.1+ ...
The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) m...
<p>(A) Absolute number of B220<sup>+</sup> B cells in BM of 12 weeks old wild-type (open bar) or SIR...
ANTIBODIES to DNA and nucleoproteins are found in sera of individuals with systemic autoimmune disea...
A-D: MFG-E8-/- mice were crossed with H564 anti-ssRNA BCR transgenic mice. The percentages and surfa...
Plasma cell differentiation of id+ B cells was examined in the spleens of 3 month old w.t. and MFG-E...
Defective clearance of apoptotic cells in MFG-E8 deficient mice results in lupus-like disease in the...
The immune system generates a diverse repertoire of B cells that recognize foreign antigens (Ags) to...
Members of the broad complex, tram track, bric-a-brac and zinc finger (BTB-ZF) family of transcripti...
A hallmark of systemic lupus erythematosus is the presence of anti-double-stranded (ds) DNA Abs that...
A: CD45.2+ 56R and H564 B cells were activated by LPS (1μg/ml) for 3 days. Activated B cells were ex...
Immunization with portions of a murine antibody to DNA induced Ig peptide-reactive peripheral CD8+ i...
The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) m...
The MHC class II gene Aa was disrupted by targeted mutation in embryonic stem (ES) cells derived fro...
Immunization of experimental autoimmune encephalomyelitis (EAE)-prone C57BL/6 mice with MOG35-55 (a ...
Serum anti-DNA Abs are diagnostic for the autoimmune disease SLE and have been implicated in renal p...
The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) m...
<p>(A) Absolute number of B220<sup>+</sup> B cells in BM of 12 weeks old wild-type (open bar) or SIR...
ANTIBODIES to DNA and nucleoproteins are found in sera of individuals with systemic autoimmune disea...
A-D: MFG-E8-/- mice were crossed with H564 anti-ssRNA BCR transgenic mice. The percentages and surfa...
Plasma cell differentiation of id+ B cells was examined in the spleens of 3 month old w.t. and MFG-E...
Defective clearance of apoptotic cells in MFG-E8 deficient mice results in lupus-like disease in the...
The immune system generates a diverse repertoire of B cells that recognize foreign antigens (Ags) to...
Members of the broad complex, tram track, bric-a-brac and zinc finger (BTB-ZF) family of transcripti...
A hallmark of systemic lupus erythematosus is the presence of anti-double-stranded (ds) DNA Abs that...
A: CD45.2+ 56R and H564 B cells were activated by LPS (1μg/ml) for 3 days. Activated B cells were ex...
Immunization with portions of a murine antibody to DNA induced Ig peptide-reactive peripheral CD8+ i...
The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) m...
The MHC class II gene Aa was disrupted by targeted mutation in embryonic stem (ES) cells derived fro...
Immunization of experimental autoimmune encephalomyelitis (EAE)-prone C57BL/6 mice with MOG35-55 (a ...
Serum anti-DNA Abs are diagnostic for the autoimmune disease SLE and have been implicated in renal p...
The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) m...
<p>(A) Absolute number of B220<sup>+</sup> B cells in BM of 12 weeks old wild-type (open bar) or SIR...
ANTIBODIES to DNA and nucleoproteins are found in sera of individuals with systemic autoimmune disea...