Comparison between bypass grafting and transient arterial ligation.

RNA sequencing pathway analysis of venous bypass grafts 1, 6, and 24h after transplantation. Data are expressed as log2 fold change compared to normal vena cava. (A) Analysis of smooth muscle cell associated pathways in response to bypass grafting. (B) Regulation of mRNA expression of genes related to smooth muscle cell quiescence in response to bypass grafting. (C) mRNA expression of venous bypass grafts (filled squares) and transiently ligated carotid arteries (transparent squares; analyzed via qPCR) after indicated reperfusion times. Data are expressed as fold change compared to normal carotid arteries. For bypass grafts and transiently ligated carotid arteries n≥4.