A randomized trial of serological and cellular responses to hepatitis B vaccination in chronic kidney disease - Fig 6

PD-1 is upregulated on CXCR3+CCR6- cTFH after vaccination, but not after HBV in CKD patients (a). Gating strategy to determine PD-1 MFI on CXCR5+ memory CD4+ T cells before (grey box and histograms) and after (colored box and histogram) vaccination, according to CXCR3 and CCR6 expression (CXCR3+CCR6- compartment shown here), followed by CCR7 expression. (b-c). Change in PD-1 MFI in CCR7+ (b) and CCR7- (c) cTFH compartments after vaccination. HC who received Fluvax (n = 10, blue circles) or HBV (n = 6, blue squares). CKD patients who received HBV (20mcg n = 9, 40mcg n = 11; black squares) or Fluvax (black circles, n = 5). Horizontal bars represent medians. *p<0.05, Bonferroni correction for α<0.05, p<0.025.