Plot of average slope decline in lung function in CFLD subjects.

(A) Points are estimated mean values (±SE), of outcome plotted at t = -5 years (before CFLD diagnosis), t = 0 years (time of CFLD diagnosis), and t = 5 years (after CFLD diagnosis) for a patient age 13.3 years (average age at CFLD diagnosis). CF-specific FEV1 percentile (solid line) and FEV1% predicted (dashed line) are shown in 118 CFLD subjects with lung function values before and after CFLD diagnosis. (B) Averaged data at t = 0 and t = 5 years (±SE), including an additional 61 patients with post-CFLD diagnosis lung function values (total subjects, n = 179).