Role of BAF250a in mediating protein-DNA and protein-protein interactions.

(A) Cartoon representation of BAF250_C and a plausible ARID-DNA complex are shown, where the surface exposed and conserved residues in ARID and BAF250_C which are further found to be mutated in various cancers in COSMIC database, are marked in orange. (B) Model of BAF250a interaction with DNA and other proteins. In the proposed model, the N-terminal ARID is shown to interact with dsDNA, while the C-terminal ARM-repeat BAF250_C can have inter-domain interaction with ARID and other proteins in the SWI/SNF complex.