Tumor DNA mutation frequency in Oral Cavity Squamous Cell Carcinomas.

DNA was sequenced from 25 subjects with OCSCC, using paired tumor and normal DNA samples, and sequence data was examined for tumor specific mutations using MuTect, MuTect2 and VarScan2 (A) Summary of total and potentially deleterious somatic short nucleotide variations. (B) Frequency of potential deleterious somatic mutations by variant classification. (C) Consistency between the three variant calling programs in calling of single nucleotide variants and indels.