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Known MRP4 inhibitors and their bioactivity.

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

Publication date

October 2018

DOI

10.1371/journal.pone.0205175.g001

Publisher

Public Library of Science (PLoS)

Abstract

Fold sensitization = (IC50 cytotoxic + DMSO)/ (IC50 cytotoxic 6-MP + inhibitor).</p

Extracted data

Related items

Cpd23 reverses 6-MP resistance conferred by MRP4.

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

October 2018

Dose-response curves for 6-MP on A) HEK293 and B) HEK293/MRP4 cells in the presence of DMSO, MK571, ...

Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal

Renes, J
De Vries, EEG
Hooiveld, GJEJ
Krikken, [No Value]
Jansen, PLM
Muller, M

September 2000

4-Hydroxynonenal (4HNE) is the most prevalent toxic lipid peroxidation product formed during oxidati...

Research Article Interaction of Oxazaphosphorines with Multidrug Resistance-Associated Protein 4 (MRP4)

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Ka-yun Ng
Paul C. Ho

January 2010

Abstract. Multidrug resistance-associated protein 4 (MRP4) is an organic anion efflux pump capable o...

Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen

Cheung, L
Yu, DMT
Neiron, Z
Failes, TW
Arndt, GM
Fletcher, JI

February 2015

Multidrug resistance protein 4 (MRP4) effluxes a wide variety of drugs and endogenous signaling mole...

IC<sub>50</sub> for 6-MP on HEK293 and HEK293/MRP4 cells independently or in the presence of MRP4 inhibitors.

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

October 2018

IC50 for 6-MP on HEK293 and HEK293/MRP4 cells independently or in the presence of MRP4 inhibitors.</...

Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

October 2018

Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter. It is asso...

Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening.

Ya Chen
Xia Yuan
Zhangping Xiao
Hongwei Jin
Liangren Zhang
Zhenming Liu

January 2018

Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter. It is asso...

Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening - Fig 9

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

October 2018

A) Structures of MK571 and Cpd23. B) Three-dimensional alignment of MK571 and Cpd23 conformers (dock...

Human multidrug resistance associated protein 4 resitance to camtothecins

Tian, Quan
Zhang, Jing
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Chan, Eli
Duan, Wei
Chan, Sui Yung
Boelsterli, Urs Alex
Ho, Paul Chi-Lui
Yang, Hongyuan
Bian, Jin-Song
Huang, Min
Zhu, Yi-Zhun
Xiong, Weiping
Li, Xiaotian
Zhou, Shufeng

November 2005

Purpose The multidrug resistance associated protein (MRP) 4 is a member of the adenosine triphosphat...

Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor

Riganti C.
Giampietro R.
Kopecka J.
Costamagna C.
Abatematteo F. S.
Contino M.
Abate C.

January 2020

Multidrug resistance (MDR) is the main obstacle to current chemotherapy and it is mainly due to the ...

Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins

Tian, Quan
Zhang, Jing
Tan, Theresa May Chin
Chan, Eli
Duan, Wei
Chan, Sui Yung
Boelsterli, Urs Alex
Ho, Paul Chi-Lui
Yang, Hongyuan
Bian, Jin-Song
Huang, Min
Zhu, Yi-Zhun
Xiong, Weiping
Li, Xiaotian
Zhou, Shufeng

November 2005

Purpose: The multidrug resistance associated protein (MRP) 4 is a member of the adenosine triphospha...

Human multidrug resistance associated protein 4 confers resistance to camptothecins

Tian, Q
Zhang, J
Tan, T
Chan, E
Duan, W
Chan, S
Boelsterli, U
Ho, P
Yang, H
Bian, J
Huang, M
Zhu, Y
Xiong, W
Li, X
Zhou, S

January 2005

Purpose The multidrug resistance associated protein (MRP) 4 is a member of the adenosine triphosphat...

Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules.

Russel, F.G.M.
Koenderink, J.B.
Masereeuw, R.

January 2008

Contains fulltext : 70675.pdf (publisher's version ) (Closed access)Multidrug resi...

Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs

Yu, X
Xue, C
Wang, G
Zhou, S

January 2007

he multidrug resistance associated proteins (MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MRP7, MRP8 and MRP9...

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4

Glen Reid
Peter Wielinga
Noam Zelcer
Marcel De Haas
Liesbeth Van Deemter
Jan Wijnholds

January 2003

The human multidrug resistance proteins MRP4 and MRP5 are organic anion transporters that have the u...

Cpd23 reverses 6-MP resistance conferred by MRP4.

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

October 2018

Dose-response curves for 6-MP on A) HEK293 and B) HEK293/MRP4 cells in the presence of DMSO, MK571, ...

Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal

Renes, J
De Vries, EEG
Hooiveld, GJEJ
Krikken, [No Value]
Jansen, PLM
Muller, M

September 2000

4-Hydroxynonenal (4HNE) is the most prevalent toxic lipid peroxidation product formed during oxidati...

Research Article Interaction of Oxazaphosphorines with Multidrug Resistance-Associated Protein 4 (MRP4)

Jing Zhang
Ka-yun Ng
Paul C. Ho

January 2010

Abstract. Multidrug resistance-associated protein 4 (MRP4) is an organic anion efflux pump capable o...

Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen

Cheung, L
Yu, DMT
Neiron, Z
Failes, TW
Arndt, GM
Fletcher, JI

February 2015

Multidrug resistance protein 4 (MRP4) effluxes a wide variety of drugs and endogenous signaling mole...

IC<sub>50</sub> for 6-MP on HEK293 and HEK293/MRP4 cells independently or in the presence of MRP4 inhibitors.

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

October 2018

IC50 for 6-MP on HEK293 and HEK293/MRP4 cells independently or in the presence of MRP4 inhibitors.</...

Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

October 2018

Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter. It is asso...

Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening.

Ya Chen
Xia Yuan
Zhangping Xiao
Hongwei Jin
Liangren Zhang
Zhenming Liu

January 2018

Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter. It is asso...

Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening - Fig 9

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

October 2018

A) Structures of MK571 and Cpd23. B) Three-dimensional alignment of MK571 and Cpd23 conformers (dock...

Human multidrug resistance associated protein 4 resitance to camtothecins

Tian, Quan
Zhang, Jing
Tan, Theresa May Chin
Chan, Eli
Duan, Wei
Chan, Sui Yung
Boelsterli, Urs Alex
Ho, Paul Chi-Lui
Yang, Hongyuan
Bian, Jin-Song
Huang, Min
Zhu, Yi-Zhun
Xiong, Weiping
Li, Xiaotian
Zhou, Shufeng

November 2005

Purpose The multidrug resistance associated protein (MRP) 4 is a member of the adenosine triphosphat...

Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor

Riganti C.
Giampietro R.
Kopecka J.
Costamagna C.
Abatematteo F. S.
Contino M.
Abate C.

January 2020

Multidrug resistance (MDR) is the main obstacle to current chemotherapy and it is mainly due to the ...

Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins

Tian, Quan
Zhang, Jing
Tan, Theresa May Chin
Chan, Eli
Duan, Wei
Chan, Sui Yung
Boelsterli, Urs Alex
Ho, Paul Chi-Lui
Yang, Hongyuan
Bian, Jin-Song
Huang, Min
Zhu, Yi-Zhun
Xiong, Weiping
Li, Xiaotian
Zhou, Shufeng

November 2005

Purpose: The multidrug resistance associated protein (MRP) 4 is a member of the adenosine triphospha...

Human multidrug resistance associated protein 4 confers resistance to camptothecins

Tian, Q
Zhang, J
Tan, T
Chan, E
Duan, W
Chan, S
Boelsterli, U
Ho, P
Yang, H
Bian, J
Huang, M
Zhu, Y
Xiong, W
Li, X
Zhou, S

January 2005

Purpose The multidrug resistance associated protein (MRP) 4 is a member of the adenosine triphosphat...

Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules.

Russel, F.G.M.
Koenderink, J.B.
Masereeuw, R.

January 2008

Contains fulltext : 70675.pdf (publisher's version ) (Closed access)Multidrug resi...

Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs

Yu, X
Xue, C
Wang, G
Zhou, S

January 2007

he multidrug resistance associated proteins (MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MRP7, MRP8 and MRP9...

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4

Glen Reid
Peter Wielinga
Noam Zelcer
Marcel De Haas
Liesbeth Van Deemter
Jan Wijnholds

January 2003

The human multidrug resistance proteins MRP4 and MRP5 are organic anion transporters that have the u...

Cpd23 reverses 6-MP resistance conferred by MRP4.

Ya Chen (1437550)
Xia Yuan (485523)
Zhangping Xiao (5855825)
Hongwei Jin (391981)
Liangren Zhang (114208)
Zhenming Liu (448850)

October 2018

Dose-response curves for 6-MP on A) HEK293 and B) HEK293/MRP4 cells in the presence of DMSO, MK571, ...

Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal

Renes, J
De Vries, EEG
Hooiveld, GJEJ
Krikken, [No Value]
Jansen, PLM
Muller, M

September 2000

4-Hydroxynonenal (4HNE) is the most prevalent toxic lipid peroxidation product formed during oxidati...

Research Article Interaction of Oxazaphosphorines with Multidrug Resistance-Associated Protein 4 (MRP4)

Jing Zhang
Ka-yun Ng
Paul C. Ho

January 2010

Abstract. Multidrug resistance-associated protein 4 (MRP4) is an organic anion efflux pump capable o...