SNX8 is essential for host defense against HSV-1 infection in mice.

(A) Snx8+/+ and Snx8-/- mice (n = 10) were infected intraperitoneally (i.p.) with HSV-1 at 1.5 × 107 pfu per mouse, and the survivals of mice were recorded daily for 12 days. (B) Snx8+/+ and Snx8-/- mice (n = 13) were infected intraperitoneally (i.p.) with HSV-1 at 1.5 × 107 pfu per mouse for 6 h before serum cytokines were measured by ELISA. (**pSnx8+/+ and Snx8-/- mice (n = 3) were infected intraperitoneally (i.p.) with HSV-1 at 1 × 107 pfu per mouse, and the brains were retrieved 6 days later for viral load measurement (left histograph) and q-PCR analysis of HSV-1 genomic copies (right histograph). (**p<0.01).