Liver X receptor α (LXRα) controls important biological and pathophysiological processes such as lipid homeostasis. Inhibiting LXRα transactivation may beneficial in the treatment of nonalcoholic fatty liver disease (NAFLD), which is one of the main causes of liver diseases and hyperlipidemia. Oleanolic acid (OA) is a naturally occurring triterpenoid found in many plants. It has several beneficial effects on biological pathways; however, the mechanisms underlying its effects on LXRα are unclear. Therefore, we evaluated the effects of OA on T0901317-induced LXRα activation and explored whether OA can attenuate hepatic lipogenesis. The results showed that OA significantly decreased the promoter activities of LXR response element and sterol re...
The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional co...
Objective. Previous studies have characterized the hepatoprotective and anti-inflammatory properties...
International audienceAlthough non-alcoholic fatty liver disease (NAFLD) is currently the most commo...
Nonalcoholic fatty liver disease (NAFLD) is a very common liver disease, and its incidence has signi...
Background Sterol regulatory element binding protein-1c (SREBP-1c) is a regulator o...
The liver X receptors (LXRs) sense oxysterols and regulate genes involved in cholesterol metabolism....
Oleanolic acid (OA), contained in more than 1620 plants and as an aglycone precursor for naturally o...
Liver X receptor (LXR) alpha and beta are nuclear receptors that control cellular metabolism. LXRs m...
Liver X receptor (LXR) alpha and beta are nuclear receptors that control cellular metabolism. LXRs m...
Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the transcript...
International audienceThe Liver X Receptors (LXRs) α and β and the Peroxisome Proliferator-Activated...
LXR alpha (liver X receptor, also called RLD-1) is a nuclear receptor, highly expressed in tissues t...
In mammals, lipogenesis or de novo fatty acid synthesis plays an essential part in energy homeostasi...
This is the publisher's version, also available electronically from "http://www.pnas.org".The pregna...
Isoliguritigenin (ILQ) a flavonoid obtained from Glycyrrhizae species has an antioxidant effect This...
The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional co...
Objective. Previous studies have characterized the hepatoprotective and anti-inflammatory properties...
International audienceAlthough non-alcoholic fatty liver disease (NAFLD) is currently the most commo...
Nonalcoholic fatty liver disease (NAFLD) is a very common liver disease, and its incidence has signi...
Background Sterol regulatory element binding protein-1c (SREBP-1c) is a regulator o...
The liver X receptors (LXRs) sense oxysterols and regulate genes involved in cholesterol metabolism....
Oleanolic acid (OA), contained in more than 1620 plants and as an aglycone precursor for naturally o...
Liver X receptor (LXR) alpha and beta are nuclear receptors that control cellular metabolism. LXRs m...
Liver X receptor (LXR) alpha and beta are nuclear receptors that control cellular metabolism. LXRs m...
Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the transcript...
International audienceThe Liver X Receptors (LXRs) α and β and the Peroxisome Proliferator-Activated...
LXR alpha (liver X receptor, also called RLD-1) is a nuclear receptor, highly expressed in tissues t...
In mammals, lipogenesis or de novo fatty acid synthesis plays an essential part in energy homeostasi...
This is the publisher's version, also available electronically from "http://www.pnas.org".The pregna...
Isoliguritigenin (ILQ) a flavonoid obtained from Glycyrrhizae species has an antioxidant effect This...
The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional co...
Objective. Previous studies have characterized the hepatoprotective and anti-inflammatory properties...
International audienceAlthough non-alcoholic fatty liver disease (NAFLD) is currently the most commo...