Additional file 1: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

Publication date

October 2018

DOI

10.6084/m9.figshare.7238663.v1

Abstract

Figure S1. Validation of Fslt1 knockdown, related to Fig.Â 3. Culture astrocytes were transfected with siRNA targeting for Fstl1 or control siRNA. Western blotting was performed with indicated antibodies. (PPTX 66 kb

Extracted data

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Additional file 1: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

Open link

Publication date

October 2018

DOI

10.6084/m9.figshare.7238663.v1

Abstract

Extracted data

Franziska Hoffmann (409961)
Johann Hofereiter (3511457)
Heike Rübsamen (3511454)
Johannes Melms (3511460)
Sigrid Schwarz (3085452)
Hans Faber (3511451)
Peter Weber (24729)
Benno Pütz (170415)
Verena Loleit (3511463)
Frank Weber (20108)
Reinhard Hohlfeld (25667)
Edgar Meinl (776341)
Markus Krumbholz (680584)

September 2015

Analysis of possible interactions between FTY-P and TNF. (A) Human U373 astrocytoma cells were stimu...

Additional file 2: Figure S2. of HAM/TSP-derived HTLV-1-infected T cell lines promote morphological and functional changes in human astrocytes cell lines: possible role in the enhanced T cells recruitment into Central Nervous System

Eduardo Gudo (3513530)
Suse Silva-Barbosa (3475835)
Leandra Linhares-Lacerda (3513539)
Marcelo Ribeiro-Alves (184765)
Suzana Real (3513536)
Dumith Bou-Habib (3513533)
Wilson Savino (63343)

October 2015

Extracellular matrix proteins gene expression in astrocytoma cell lines after transient exposure to ...

Additional file 3: of The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Sofia Söllvander (3402770)
Elisabeth Nikitidou (3402773)
Linn Gallasch (5038016)
Marlena Zyśk (5038013)
Linda Söderberg (3402776)
Dag Sehlin (333061)
Lars Lannfelt (333066)
Anna Erlandsson (175907)

March 2018

The mAb1C3 lowers Aβ inclusions in astrocytes. Aβ42 protofibrils were accumulated in astrocytes (A),...

Additional file 2: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S2. Effect of rFstl1 treatment on neurite branch, related to Fig. 4. Neurons were treated wit...

Additional file 3: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S3. Effect of rFstl1 treatment on cell viability, related to Fig. 4. Neurons were treated wit...

Additional file 5: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S5. Expression of Fstl1 in polyI:C-treated Ifitm3 KO mice, related to Fig. 5. Hippocampal bra...

Additional file 4: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S4. Co-expression of Fstl1 with Ifitm3 in the hippocampus of polyI:C-treated neonatal mice, r...

Additional file 6: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S6. Combinatory treatment of rBmp4 with rFstl1, related to Fig. 4. Neurons were cultured for ...

Additional file 1: Figure S1. of Fingolimod induces neuroprotective factors in human astrocytes

Franziska Hoffmann (409961)
Johann Hofereiter (3511457)
Heike Rübsamen (3511454)
Johannes Melms (3511460)
Sigrid Schwarz (3085452)
Hans Faber (3511451)
Peter Weber (24729)
Benno Pütz (170415)
Verena Loleit (3511463)
Frank Weber (20108)
Reinhard Hohlfeld (25667)
Edgar Meinl (776341)
Markus Krumbholz (680584)

September 2015

Validation of different house-keeping genes for quantitative PCR in human astrocytes or U373 astrocy...

Additional file 1: Figure S1. of Fstl1 is involved in the regulation of radial glial scaffold development

Rui Liu (54031)
Yang Yang (45629)
Junhui Shen (426075)
He Chen (104732)
Qianqian Zhang (587342)
Ru Ba (3572483)
Yongjie Wei (2430100)
Kai-Cheng Li (3572480)
Xu Zhang (49484)
Chunjie Zhao (337669)

September 2015

The neurogenesis of upper-layer neurons was not affected by Fstl1 deletion. (A to D’) IPCs at E13.5 ...

Additional file 3: Figure S3. of Fstl1 is involved in the regulation of radial glial scaffold development

Rui Liu (54031)
Yang Yang (45629)
Junhui Shen (426075)
He Chen (104732)
Qianqian Zhang (587342)
Ru Ba (3572483)
Yongjie Wei (2430100)
Kai-Cheng Li (3572480)
Xu Zhang (49484)
Chunjie Zhao (337669)

September 2015

Analysis of the possible mechanisms by which Fstl1 regulates the development of radial glial process...

Additional file 2: of Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis

Hanane Touil (5123441)
Antonia Kobert (5123450)
Nathalie Lebeurrier (5123444)
Aja Rieger (5123453)
Philippe Saikali (5123447)
Caroline Lambert (1087664)
Lama Fawaz (5123456)
Craig Moore (618293)
Alexandre Prat (153165)
Jennifer Gommerman (153077)
Jack Antel (448163)
Yasuto Itoyama (18208)
Ichiro Nakashima (3574049)
Amit Bar-Or (618298)

April 2018

Figure S1. Confirming activation of human astrocytes. Astrocytes were cultured for 24 h and were eit...

Additional file 3: Figure S3. of Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

Shamsudheen Moidunny (3504302)
Marco Matos (3504314)
Evelyn Wesseling (3504308)
Santanu Banerjee (101828)
David Volsky (3504311)
Rodrigo Cunha (3504305)
Paula Agostinho (1969096)
Hendrikus Boddeke (3504317)
Sabita Roy (101851)

June 2016

Primary mouse astrocyte cultures differentially express GLAST and GLT-1 transporters. (A) Cortical a...

Additional file 1: Figure S1. of HAM/TSP-derived HTLV-1-infected T cell lines promote morphological and functional changes in human astrocytes cell lines: possible role in the enhanced T cells recruitment into Central Nervous System

Eduardo Gudo (3513530)
Suse Silva-Barbosa (3475835)
Leandra Linhares-Lacerda (3513539)
Marcelo Ribeiro-Alves (184765)
Suzana Real (3513536)
Dumith Bou-Habib (3513533)
Wilson Savino (63343)

October 2015

Cytokine/Chemokine gene expression in astrocytoma cell line after transient exposure to supernatants...

Additional file 5: Figure S3. of Fingolimod induces neuroprotective factors in human astrocytes

Franziska Hoffmann (409961)
Johann Hofereiter (3511457)
Heike Rübsamen (3511454)
Johannes Melms (3511460)
Sigrid Schwarz (3085452)
Hans Faber (3511451)
Peter Weber (24729)
Benno Pütz (170415)
Verena Loleit (3511463)
Frank Weber (20108)
Reinhard Hohlfeld (25667)
Edgar Meinl (776341)
Markus Krumbholz (680584)

September 2015

Analysis of possible interactions between FTY-P and TNF. (A) Human U373 astrocytoma cells were stimu...

Eduardo Gudo (3513530)
Suse Silva-Barbosa (3475835)
Leandra Linhares-Lacerda (3513539)
Marcelo Ribeiro-Alves (184765)
Suzana Real (3513536)
Dumith Bou-Habib (3513533)
Wilson Savino (63343)

October 2015

Extracellular matrix proteins gene expression in astrocytoma cell lines after transient exposure to ...

Additional file 3: of The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Sofia Söllvander (3402770)
Elisabeth Nikitidou (3402773)
Linn Gallasch (5038016)
Marlena Zyśk (5038013)
Linda Söderberg (3402776)
Dag Sehlin (333061)
Lars Lannfelt (333066)
Anna Erlandsson (175907)

March 2018

The mAb1C3 lowers Aβ inclusions in astrocytes. Aβ42 protofibrils were accumulated in astrocytes (A),...

Additional file 2: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S2. Effect of rFstl1 treatment on neurite branch, related to Fig. 4. Neurons were treated wit...

Additional file 3: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S3. Effect of rFstl1 treatment on cell viability, related to Fig. 4. Neurons were treated wit...

Additional file 5: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S5. Expression of Fstl1 in polyI:C-treated Ifitm3 KO mice, related to Fig. 5. Hippocampal bra...

Additional file 4: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S4. Co-expression of Fstl1 with Ifitm3 in the hippocampus of polyI:C-treated neonatal mice, r...

Additional file 6: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada (5880836)
Norimichi Itoh (5880839)
Taku Nagai (840872)
Tsuyoshi Nakai (5880842)
Daisuke Ibi (5880845)
Akira Nakajima (86971)
Toshitaka Nabeshima (238835)
Kiyofumi Yamada (840471)

October 2018

Figure S6. Combinatory treatment of rBmp4 with rFstl1, related to Fig. 4. Neurons were cultured for ...

Additional file 1: Figure S1. of Fingolimod induces neuroprotective factors in human astrocytes

Franziska Hoffmann (409961)
Johann Hofereiter (3511457)
Heike Rübsamen (3511454)
Johannes Melms (3511460)
Sigrid Schwarz (3085452)
Hans Faber (3511451)
Peter Weber (24729)
Benno Pütz (170415)
Verena Loleit (3511463)
Frank Weber (20108)
Reinhard Hohlfeld (25667)
Edgar Meinl (776341)
Markus Krumbholz (680584)

September 2015

Validation of different house-keeping genes for quantitative PCR in human astrocytes or U373 astrocy...

Additional file 1: Figure S1. of Fstl1 is involved in the regulation of radial glial scaffold development

Rui Liu (54031)
Yang Yang (45629)
Junhui Shen (426075)
He Chen (104732)
Qianqian Zhang (587342)
Ru Ba (3572483)
Yongjie Wei (2430100)
Kai-Cheng Li (3572480)
Xu Zhang (49484)
Chunjie Zhao (337669)

September 2015

The neurogenesis of upper-layer neurons was not affected by Fstl1 deletion. (A to D’) IPCs at E13.5 ...

Additional file 3: Figure S3. of Fstl1 is involved in the regulation of radial glial scaffold development

Rui Liu (54031)
Yang Yang (45629)
Junhui Shen (426075)
He Chen (104732)
Qianqian Zhang (587342)
Ru Ba (3572483)
Yongjie Wei (2430100)
Kai-Cheng Li (3572480)
Xu Zhang (49484)
Chunjie Zhao (337669)

September 2015

Analysis of the possible mechanisms by which Fstl1 regulates the development of radial glial process...

Additional file 2: of Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis

Hanane Touil (5123441)
Antonia Kobert (5123450)
Nathalie Lebeurrier (5123444)
Aja Rieger (5123453)
Philippe Saikali (5123447)
Caroline Lambert (1087664)
Lama Fawaz (5123456)
Craig Moore (618293)
Alexandre Prat (153165)
Jennifer Gommerman (153077)
Jack Antel (448163)
Yasuto Itoyama (18208)
Ichiro Nakashima (3574049)
Amit Bar-Or (618298)

April 2018

Figure S1. Confirming activation of human astrocytes. Astrocytes were cultured for 24 h and were eit...

Additional file 3: Figure S3. of Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

Shamsudheen Moidunny (3504302)
Marco Matos (3504314)
Evelyn Wesseling (3504308)
Santanu Banerjee (101828)
David Volsky (3504311)
Rodrigo Cunha (3504305)
Paula Agostinho (1969096)
Hendrikus Boddeke (3504317)
Sabita Roy (101851)

June 2016

Primary mouse astrocyte cultures differentially express GLAST and GLT-1 transporters. (A) Cortical a...

Eduardo Gudo (3513530)
Suse Silva-Barbosa (3475835)
Leandra Linhares-Lacerda (3513539)
Marcelo Ribeiro-Alves (184765)
Suzana Real (3513536)
Dumith Bou-Habib (3513533)
Wilson Savino (63343)

October 2015

Cytokine/Chemokine gene expression in astrocytoma cell line after transient exposure to supernatants...

Additional file 5: Figure S3. of Fingolimod induces neuroprotective factors in human astrocytes

Franziska Hoffmann (409961)
Johann Hofereiter (3511457)
Heike Rübsamen (3511454)
Johannes Melms (3511460)
Sigrid Schwarz (3085452)
Hans Faber (3511451)
Peter Weber (24729)
Benno Pütz (170415)
Verena Loleit (3511463)
Frank Weber (20108)
Reinhard Hohlfeld (25667)
Edgar Meinl (776341)
Markus Krumbholz (680584)

September 2015

Analysis of possible interactions between FTY-P and TNF. (A) Human U373 astrocytoma cells were stimu...

Eduardo Gudo (3513530)
Suse Silva-Barbosa (3475835)
Leandra Linhares-Lacerda (3513539)
Marcelo Ribeiro-Alves (184765)
Suzana Real (3513536)
Dumith Bou-Habib (3513533)
Wilson Savino (63343)

October 2015

Extracellular matrix proteins gene expression in astrocytoma cell lines after transient exposure to ...

Additional file 3: of The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Sofia Söllvander (3402770)
Elisabeth Nikitidou (3402773)
Linn Gallasch (5038016)
Marlena Zyśk (5038013)
Linda Söderberg (3402776)
Dag Sehlin (333061)
Lars Lannfelt (333066)
Anna Erlandsson (175907)

March 2018

The mAb1C3 lowers Aβ inclusions in astrocytes. Aβ42 protofibrils were accumulated in astrocytes (A),...

Additional file 1: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Abstract

Extracted data

Additional file 1: of Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Abstract

Extracted data

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