Comparison of human (pale green, pink, magenta) and rat (yellow, red, blue) RIP2 CARD domain structures, reported here and in the work by Lin et al [13].

A,B,C—overlay of the structures in ribbon representation. B demonstrates the different conformation of the P518 peptide bond. C shows the differences in the positions of charged residues in H1. D—structure of RIP2CARD with indicated and assigned residues that are important for the proper packing of C-terminal residues.