Effects of resveratrol on cell viability of osteoblastic cells and osteosarcoma cells.

(A) Cell viability of hFOB 1.19, MG-63 and MNNG/HOS with gradient resveratrol for 48 h. IC50 values were estimated with a nonlinear regression model with GraphPad Prism version 7.0. (B) The percentage of cell viability inhibition of hFOB 1.19, MG-63 and MNNG/HOS cells with the treatment of resveratrol (0, 10, 20 or 40 μM). (C) Xenografts growth of MG-63 cells with the treatment of resveratrol. Mice were treated with intravenous infusion in the control group and resveratrol group every other day. Tumor volume was measured in the indicated day. The curves show the mean volumes of tumor size at different time points. (D) Xenografts were harvested and imagined after 21 days. The tumor volumes were compared between the resveratrol and vehicle threated groups. Bar = 1 cm. Data represent the means ± SD. *P<0.05.