MOESM4 of CD25 and TGF-Î˛ blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Ning Pu (3875413)
Guochao Zhao (5898701)
Hanlin Yin (5898704)
Jian-ang Li (4605988)
Abulimiti Nuerxiati (5898707)
Dansong Wang (4605997)
Xuefeng Xu (805221)
Tiantao Kuang (4606000)
Dayong Jin (318266)
Wenhui Lou (4605994)
Wenchuan Wu (5898710)

Publication date

October 2018

DOI

10.6084/m9.figshare.7257347.v1

Abstract

Additional file 4: Figure S3. The changes of peripheral T cell cohorts and PD-1 expression after treatments with anti-CD25, anti-TGF-Î˛ and anti-PD-1. Flow cytometry gating schema and density plots for (A) CD3+CD45+PD-1+ T cells, (B) CD3+CD45+ T cells, (C) CD3+CD4+ or CD3+CD8+ T cells and (D) CD3+CD4+FoxP3+ Tregs

Extracted data

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Data Protection

MOESM4 of CD25 and TGF-Î˛ blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Ning Pu (3875413)
Guochao Zhao (5898701)
Hanlin Yin (5898704)
Jian-ang Li (4605988)
Abulimiti Nuerxiati (5898707)
Dansong Wang (4605997)
Xuefeng Xu (805221)
Tiantao Kuang (4606000)
Dayong Jin (318266)
Wenhui Lou (4605994)
Wenchuan Wu (5898710)

Open link

Publication date

October 2018

DOI

10.6084/m9.figshare.7257347.v1

Abstract

Extracted data

A. Heeren (3539375)
J. Rotman (5744186)
A. Stam (6329021)
N. Pocorni (6329024)
A. Gassama (6329027)
S. Samuels (6329030)
M. Bleeker (6329036)
C. Mom (5744189)
H. Zijlmans (6329042)
G. Kenter (5744204)
E. Jordanova (5744195)
T. Gruijl (6329048)

February 2019

Figure S3. The IFNÎł ELISPOT reactivity in LN-, LN+ and PT single cell suspensions. (PDF 380 kb

Data_Sheet_1_Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells.pdf

Laia Gorchs (6626561)
Carlos Fernández Moro (3339789)
Peter Bankhead (178479)
Katharina P. Kern (6626564)
Imrul Sadeak (6626567)
Qingda Meng (5479709)
Elena Rangelova (6626570)
Helen Kaipe (6626573)

April 2019

Carcinoma-associated pancreatic fibroblasts (CAFs) are the major type of cells in the stroma of panc...

FIGURE 3 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Jesus Amo-Aparicio (17013541)
Adrian Dominguez (17013544)
Shaikh M. Atif (17013547)
Alberto Dinarello (17013550)
Tania Azam (17013553)
Kibrom M. Alula (17013556)
Miles Piper (15035907)
Christopher H. Lieu (15018279)
Robert W. Lentz (17013559)
Alexis D. Leal (17013562)
Stacey M. Bagby (17013565)
Wells A. Messersmith (17013568)
Sana D. Karam (17013571)
Charles A. Dinarello (17013574)
Todd M. Pitts (17013577)
Carlo Marchetti (17013580)

September 2023

NLRP3 inhibition reduces PDAC progression. A, Tumor volume and weight in WT and Nlrp3−/− mice (n = 8...

MOESM3 of CD25 and TGF-Î˛ blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Ning Pu (3875413)
Guochao Zhao (5898701)
Hanlin Yin (5898704)
Jian-ang Li (4605988)
Abulimiti Nuerxiati (5898707)
Dansong Wang (4605997)
Xuefeng Xu (805221)
Tiantao Kuang (4606000)
Dayong Jin (318266)
Wenhui Lou (4605994)
Wenchuan Wu (5898710)

October 2018

Additional file 3: Figure S2. The PD-1/PD-L1 expression in tumor tissue after treatments with anti-C...

MOESM1 of CD25 and TGF-Î˛ blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Ning Pu (3875413)
Guochao Zhao (5898701)
Hanlin Yin (5898704)
Jian-ang Li (4605988)
Abulimiti Nuerxiati (5898707)
Dansong Wang (4605997)
Xuefeng Xu (805221)
Tiantao Kuang (4606000)
Dayong Jin (318266)
Wenhui Lou (4605994)
Wenchuan Wu (5898710)

October 2018

Additional file 1: Table S1. Relationships between FoxP3+ and CD8+ infiltrating T cells and clinicop...

CD25 and TGF-β blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Ning Pu
Guochao Zhao
Hanlin Yin
Jian-ang Li
Abulimiti Nuerxiati
Dansong Wang
Xuefeng Xu
Tiantao Kuang
Dayong Jin
Wenhui Lou
Wenchuan Wu

October 2018

Abstract Background The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor due to the...

Additional file 1: of Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

May Saung (5961734)
Stephen Muth (5961737)
Ding Ding (346784)
Dwayne Thomas (5961740)
Alex Blair (5961743)
Takahiro Tsujikawa (5809061)
Lisa Coussens (714916)
Elizabeth Jaffee (2029204)
Lei Zheng (106363)

November 2018

Figure S1. PD-1 expression on CD4+ and CD8+ T-cells can increase with the addition of αCSF-1R to GVA...

Additional file 2: of Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

May Saung (5961734)
Stephen Muth (5961737)
Ding Ding (346784)
Dwayne Thomas (5961740)
Alex Blair (5961743)
Takahiro Tsujikawa (5809061)
Lisa Coussens (714916)
Elizabeth Jaffee (2029204)
Lei Zheng (106363)

November 2018

Figure S2. PD-1 + CD137+ expression increases when αCSF-1R is administered before and after GVAX vac...

MOESM2 of Tumor-infiltrating CD4+ T cells in patients with gastric cancer

Long Yuan (2617487)
Benling Xu (4638397)
Peng Yuan (150866)
Jinxue Zhou (3513452)
Peng Qin (403073)
Lu Han (151620)
Guangyu Chen (602356)
Zhenlei Wang (4638400)
Zengci Run (4638403)
Peng Zhao (128233)
Quanli Gao (385088)

December 2017

Additional file 2: Figure S2. Expression of inhibitory molecules Tim-3+ and PD-1+ on CD8+. (A) Flow ...

Additional file 4: of Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

A. Heeren (3539375)
J. Rotman (5744186)
A. Stam (6329021)
N. Pocorni (6329024)
A. Gassama (6329027)
S. Samuels (6329030)
M. Bleeker (6329036)
C. Mom (5744189)
H. Zijlmans (6329042)
G. Kenter (5744204)
E. Jordanova (5744195)
T. Gruijl (6329048)

February 2019

Figure S2. Co-expression of immune checkpoint receptors on CD8+ T-cell subsets. (PDF 1990 kb

MOESM3 of Tumor-infiltrating CD4+ T cells in patients with gastric cancer

Long Yuan (2617487)
Benling Xu (4638397)
Peng Yuan (150866)
Jinxue Zhou (3513452)
Peng Qin (403073)
Lu Han (151620)
Guangyu Chen (602356)
Zhenlei Wang (4638400)
Zengci Run (4638403)
Peng Zhao (128233)
Quanli Gao (385088)

December 2017

Additional file 3: Figure S3. Effects of PD-1+ and Tim-3+ inhibition on IFN-Îł induction. (A) Flow c...

Additional file 3: of α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

E. Dodagatta-Marri (6423848)
D. Meyer (6423851)
M. Reeves (6423854)
R. Paniagua (6423857)
M. To (6423860)
M. Binnewies (6423863)
M. Broz (6423866)
H. Mori (6423869)
D. Wu (2463043)
M. Adoumie (6423872)
R. Rosario (6423875)
O. Li (6423878)
T. Buchmann (6423881)
B. Liang (3974165)
J. Malato (6423884)
F. Arce Vargus (6423887)
D. Sheppard (6423890)
B. Hann (6423893)
A. Mirza (6423896)
S. Quezada (6423899)
M. Rosenblum (3040011)
M. Krummel (6423902)
A. Balmain (6423905)
R. Akhurst (6423908)

March 2019

Figure S1. Growth responses of CCK62 and GEK1428 to immunotherapy. Figure S2. CCK168 responses to α-...

Additional file 6: of Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

A. Heeren (3539375)
J. Rotman (5744186)
A. Stam (6329021)
N. Pocorni (6329024)
A. Gassama (6329027)
S. Samuels (6329030)
M. Bleeker (6329036)
C. Mom (5744189)
H. Zijlmans (6329042)
G. Kenter (5744204)
E. Jordanova (5744195)
T. Gruijl (6329048)

February 2019

Figure S4. Cytokine expression upon anti-CD3 stimulation: CD8+ vs. CD4+ T cells. (PDF 822 kb

Additional file 8 of N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Zhenchuan Liu (9185108)
Tingting Wang (123983)
Yunlang She (6599117)
Kaiqing Wu (1492621)
Shaorui Gu (9185111)
Lei Li (29537)
Chenglai Dong (9185114)
Chang Chen (30907)
Yongxin Zhou (11308649)

August 2021

Additional file 8: Figure S8. PKP3/PD-L1 axis inhibition enhances the efficacy of anti-PD-1 therapy....

Pancreatic cancer alters human CD4+ T lymphocyte function: a piece in the immune evasion puzzle.

Fogar, Paola
Basso, Daniela
E., Fadi
Greco, Eliana
G., Pantano
Padoan, Andrea
Bozzato, Dania
Facco, Monica
M. C., Sanzari
S., Teolato
Zambon, CARLO-FEDERICO
F., Navaglia
Semenzato, GIANPIETRO CARLO
Pedrazzoli, Sergio
Plebani, Mario

January 2011

Objectives: To verify whether the dysregulation of CD4(+) T cells concurs in worsening the outcome o...

Additional file 5: of Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

A. Heeren (3539375)
J. Rotman (5744186)
A. Stam (6329021)
N. Pocorni (6329024)
A. Gassama (6329027)
S. Samuels (6329030)
M. Bleeker (6329036)
C. Mom (5744189)
H. Zijlmans (6329042)
G. Kenter (5744204)
E. Jordanova (5744195)
T. Gruijl (6329048)

February 2019

Figure S3. The IFNÎł ELISPOT reactivity in LN-, LN+ and PT single cell suspensions. (PDF 380 kb

Data_Sheet_1_Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells.pdf

Laia Gorchs (6626561)
Carlos Fernández Moro (3339789)
Peter Bankhead (178479)
Katharina P. Kern (6626564)
Imrul Sadeak (6626567)
Qingda Meng (5479709)
Elena Rangelova (6626570)
Helen Kaipe (6626573)

April 2019

Carcinoma-associated pancreatic fibroblasts (CAFs) are the major type of cells in the stroma of panc...

FIGURE 3 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Jesus Amo-Aparicio (17013541)
Adrian Dominguez (17013544)
Shaikh M. Atif (17013547)
Alberto Dinarello (17013550)
Tania Azam (17013553)
Kibrom M. Alula (17013556)
Miles Piper (15035907)
Christopher H. Lieu (15018279)
Robert W. Lentz (17013559)
Alexis D. Leal (17013562)
Stacey M. Bagby (17013565)
Wells A. Messersmith (17013568)
Sana D. Karam (17013571)
Charles A. Dinarello (17013574)
Todd M. Pitts (17013577)
Carlo Marchetti (17013580)

September 2023

NLRP3 inhibition reduces PDAC progression. A, Tumor volume and weight in WT and Nlrp3−/− mice (n = 8...

MOESM3 of CD25 and TGF-Î˛ blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Ning Pu (3875413)
Guochao Zhao (5898701)
Hanlin Yin (5898704)
Jian-ang Li (4605988)
Abulimiti Nuerxiati (5898707)
Dansong Wang (4605997)
Xuefeng Xu (805221)
Tiantao Kuang (4606000)
Dayong Jin (318266)
Wenhui Lou (4605994)
Wenchuan Wu (5898710)

October 2018

Additional file 3: Figure S2. The PD-1/PD-L1 expression in tumor tissue after treatments with anti-C...

MOESM1 of CD25 and TGF-Î˛ blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Ning Pu (3875413)
Guochao Zhao (5898701)
Hanlin Yin (5898704)
Jian-ang Li (4605988)
Abulimiti Nuerxiati (5898707)
Dansong Wang (4605997)
Xuefeng Xu (805221)
Tiantao Kuang (4606000)
Dayong Jin (318266)
Wenhui Lou (4605994)
Wenchuan Wu (5898710)

October 2018

Additional file 1: Table S1. Relationships between FoxP3+ and CD8+ infiltrating T cells and clinicop...

Additional file 1: of Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

May Saung (5961734)
Stephen Muth (5961737)
Ding Ding (346784)
Dwayne Thomas (5961740)
Alex Blair (5961743)
Takahiro Tsujikawa (5809061)
Lisa Coussens (714916)
Elizabeth Jaffee (2029204)
Lei Zheng (106363)

November 2018

Figure S1. PD-1 expression on CD4+ and CD8+ T-cells can increase with the addition of αCSF-1R to GVA...

Additional file 2: of Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

May Saung (5961734)
Stephen Muth (5961737)
Ding Ding (346784)
Dwayne Thomas (5961740)
Alex Blair (5961743)
Takahiro Tsujikawa (5809061)
Lisa Coussens (714916)
Elizabeth Jaffee (2029204)
Lei Zheng (106363)

November 2018

Figure S2. PD-1 + CD137+ expression increases when αCSF-1R is administered before and after GVAX vac...

MOESM2 of Tumor-infiltrating CD4+ T cells in patients with gastric cancer

Long Yuan (2617487)
Benling Xu (4638397)
Peng Yuan (150866)
Jinxue Zhou (3513452)
Peng Qin (403073)
Lu Han (151620)
Guangyu Chen (602356)
Zhenlei Wang (4638400)
Zengci Run (4638403)
Peng Zhao (128233)
Quanli Gao (385088)

December 2017

Additional file 2: Figure S2. Expression of inhibitory molecules Tim-3+ and PD-1+ on CD8+. (A) Flow ...

Additional file 4: of Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

A. Heeren (3539375)
J. Rotman (5744186)
A. Stam (6329021)
N. Pocorni (6329024)
A. Gassama (6329027)
S. Samuels (6329030)
M. Bleeker (6329036)
C. Mom (5744189)
H. Zijlmans (6329042)
G. Kenter (5744204)
E. Jordanova (5744195)
T. Gruijl (6329048)

February 2019

Figure S2. Co-expression of immune checkpoint receptors on CD8+ T-cell subsets. (PDF 1990 kb

MOESM3 of Tumor-infiltrating CD4+ T cells in patients with gastric cancer

Long Yuan (2617487)
Benling Xu (4638397)
Peng Yuan (150866)
Jinxue Zhou (3513452)
Peng Qin (403073)
Lu Han (151620)
Guangyu Chen (602356)
Zhenlei Wang (4638400)
Zengci Run (4638403)
Peng Zhao (128233)
Quanli Gao (385088)

December 2017

Additional file 3: Figure S3. Effects of PD-1+ and Tim-3+ inhibition on IFN-Îł induction. (A) Flow c...

E. Dodagatta-Marri (6423848)
D. Meyer (6423851)
M. Reeves (6423854)
R. Paniagua (6423857)
M. To (6423860)
M. Binnewies (6423863)
M. Broz (6423866)
H. Mori (6423869)
D. Wu (2463043)
M. Adoumie (6423872)
R. Rosario (6423875)
O. Li (6423878)
T. Buchmann (6423881)
B. Liang (3974165)
J. Malato (6423884)
F. Arce Vargus (6423887)
D. Sheppard (6423890)
B. Hann (6423893)
A. Mirza (6423896)
S. Quezada (6423899)
M. Rosenblum (3040011)
M. Krummel (6423902)
A. Balmain (6423905)
R. Akhurst (6423908)

March 2019

Figure S1. Growth responses of CCK62 and GEK1428 to immunotherapy. Figure S2. CCK168 responses to α-...

Additional file 6: of Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

A. Heeren (3539375)
J. Rotman (5744186)
A. Stam (6329021)
N. Pocorni (6329024)
A. Gassama (6329027)
S. Samuels (6329030)
M. Bleeker (6329036)
C. Mom (5744189)
H. Zijlmans (6329042)
G. Kenter (5744204)
E. Jordanova (5744195)
T. Gruijl (6329048)

February 2019

Figure S4. Cytokine expression upon anti-CD3 stimulation: CD8+ vs. CD4+ T cells. (PDF 822 kb

Additional file 8 of N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Zhenchuan Liu (9185108)
Tingting Wang (123983)
Yunlang She (6599117)
Kaiqing Wu (1492621)
Shaorui Gu (9185111)
Lei Li (29537)
Chenglai Dong (9185114)
Chang Chen (30907)
Yongxin Zhou (11308649)

August 2021

Additional file 8: Figure S8. PKP3/PD-L1 axis inhibition enhances the efficacy of anti-PD-1 therapy....

Pancreatic cancer alters human CD4+ T lymphocyte function: a piece in the immune evasion puzzle.

Fogar, Paola
Basso, Daniela
E., Fadi
Greco, Eliana
G., Pantano
Padoan, Andrea
Bozzato, Dania
Facco, Monica
M. C., Sanzari
S., Teolato
Zambon, CARLO-FEDERICO
F., Navaglia
Semenzato, GIANPIETRO CARLO
Pedrazzoli, Sergio
Plebani, Mario

January 2011

Objectives: To verify whether the dysregulation of CD4(+) T cells concurs in worsening the outcome o...

Additional file 5: of Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

A. Heeren (3539375)
J. Rotman (5744186)
A. Stam (6329021)
N. Pocorni (6329024)
A. Gassama (6329027)
S. Samuels (6329030)
M. Bleeker (6329036)
C. Mom (5744189)
H. Zijlmans (6329042)
G. Kenter (5744204)
E. Jordanova (5744195)
T. Gruijl (6329048)

February 2019

Figure S3. The IFNÎł ELISPOT reactivity in LN-, LN+ and PT single cell suspensions. (PDF 380 kb

Data_Sheet_1_Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells.pdf

Laia Gorchs (6626561)
Carlos Fernández Moro (3339789)
Peter Bankhead (178479)
Katharina P. Kern (6626564)
Imrul Sadeak (6626567)
Qingda Meng (5479709)
Elena Rangelova (6626570)
Helen Kaipe (6626573)

April 2019

Carcinoma-associated pancreatic fibroblasts (CAFs) are the major type of cells in the stroma of panc...

FIGURE 3 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Jesus Amo-Aparicio (17013541)
Adrian Dominguez (17013544)
Shaikh M. Atif (17013547)
Alberto Dinarello (17013550)
Tania Azam (17013553)
Kibrom M. Alula (17013556)
Miles Piper (15035907)
Christopher H. Lieu (15018279)
Robert W. Lentz (17013559)
Alexis D. Leal (17013562)
Stacey M. Bagby (17013565)
Wells A. Messersmith (17013568)
Sana D. Karam (17013571)
Charles A. Dinarello (17013574)
Todd M. Pitts (17013577)
Carlo Marchetti (17013580)

September 2023

NLRP3 inhibition reduces PDAC progression. A, Tumor volume and weight in WT and Nlrp3−/− mice (n = 8...

MOESM4 of CD25 and TGF-Î˛ blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Abstract

Extracted data

MOESM4 of CD25 and TGF-Î˛ blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Abstract

Extracted data

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