Cell apoptosis in the livers of OLETF rats administered either PBS or rimonabant for 6 weeks.

(A) MDA concentrations were normalized to their respective protein concentrations and expressed as fold change compared to LETO control group (LETO Con). (B) TUNEL-positive apoptotic hepatocytes showing red under a confocal microscope (scale bars, 50 μm; magnification, 800 X). (C) Semi-quantification of TUNEL-positive cells from four randomly selected fields were normalized to LETO rats (LETO Con). Results are represented as mean ± SEM (n = 4–5 per group). *P < 0.05, **P < 0.01 compared to OLETF control rats (OLETF con). #P < 0.05 compared to rimonabant-treated OLETF rats (OLETF rimonabant).