Decrease in egg size and oviposition in <i>S</i>. <i>mansoni</i> females exposed to 20 μM GSK343 for 24 or 48 h.

Scanning electron microscopy of eggs; note that the size bar is shown within the black thin line below each image. (A) Micrographs of eggs from control females not exposed to the compound (0.1% DMSO); panels 1 and 3: Oval egg with normal lateral spine (s) at 24 and 48 h (Bar = 40 μm); panels 2 and 4: the surface of the eggs shows normal micro spicules at 24 and 48 h incubation (Bar = 2 μm). Micrographs of eggs from females exposed to GSK343 (20 μM); panels 5 and 7: Reduced egg size with lateral spine (s) at 24 and 48 h of treatment (Bar = 40 μm); panels 6 and 8: the surface of the eggs show fissures at 24 and 48 h (Bar = 2 μm; 3 μm). (B and C) Total area dimension of S. mansoni eggs and number of eggs released by females incubated with GSK343 (20 μM) or vehicle (0.1% DMSO), respectively. *** p < 0.001.